This lecture presents the Medical Informatics Platform's data federation in epilepsy.

This lecture aims to help researchers, students, and health care professionals understand the place for neuroinformatics in the patient journey using the exemplar of an epilepsy patient. 

In this lesson, the simulation of a virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved clinical results. You will learn about the fundamentals of epilepsy, as well as the concepts underlying epilepsy simulation. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

Explore how to setup an epileptic seizure simulation with the TVB graphical user interface. This lesson will show you how to program the epileptor model in the brain network to simulate a epileptic seizure originating in the hippocampus. It will also show how to upload and view mouse connectivity data, as well as give a short introduction to the python script interface of TVB.

In this lesson you will learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper On the Nature of Seizure Dynamics, which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

This talk introduces data sharing initiatives in Epilepsy, particularly across Europe.

The epilepsy SP actively promotes and supports epilepsy-related issues as well as educational and scientific activities within the framework of EAN. Our partners ILAE/ILAE Europe, EpiCare, EPNS and AOAN are actively involved. One of the major tasks is promoting submissions of session proposals for EAN congress balancing new scientific approaches and educational need for teaching courses. Outside of congress activities, contributions to e-learning facilities on the EAN website such as registrars reading list, scales and scores and breaking news are regularly presented or updated. Particular since the COVID pandemic, publications on COVID and any issues of epilepsy or seizures are regularly screened and summarized in neurology updates. In partnership with the ILAE/ILAE Europe, several guidelines are under preparation.

This lesson continues with the second workshop on reproducible science, focusing on additional open source tools for researchers and data scientists, such as the R programming language for data science, as well as associated tools like RStudio and R Markdown. Additionally, users are introduced to Python and iPython notebooks, Google Colab, and are given hands-on tutorials on how to create a Binder environment, as well as various containers in Docker and Singularity.

This talk goes over Neurobagel, an open-source platform developed for improved dataset sharing and searching. 

In this lesson, you will learn about the BRAIN Initiative Cell Atlas Network (BICAN) and how this project adopts a federated approach to data sharing. 

In this second part of the lecture Data Science and Reproducibility, you will learn how to apply the awareness of the intersection between neuroscience and data science (discussed in part one) to an understanding of the current reproducibility crisis in biomedical science and neuroscience. 

This lecture covers the benefits and difficulties involved when re-using open datasets, and how metadata is important to the process.

This lesson provides a quick tour of some data repositories and how to download and manipulate data from them.

In this lesson, attendees will learn about the data structure standards, specifically the Brain Imaging Data Structure (BIDS), an INCF-endorsed standard for organizing, annotating, and describing data collected during neuroimaging experiments. 

This talks discusses data sharing in the context of dementia. It explains why data sharing in dementia is important, how data is usually shared in the field and illustrates two examples: the Netherlands Consortium Dementia cohorts and the European Platform for Neurodegenerative Diseases.

The Medical Informatics Platform (MIP) Dementia had been installed in several memory clinics across Europe allowing them to federate their real-world databases. Research open access databases had also been integrated such as ADNI (Alzheimer’s Dementia Neuroimaging Initiative), reaching a cumulative case load of more than 5,000 patients (major cognitive disorder due to Alzheimer’s disease, other major cognitive disorder, minor cognitive disorder, controls). The statistic and machine learning tools implemented in the MIP allowed researchers to conduct easily federated analyses among Italian memory clinics (Redolfi et al. 2020) and also across borders between the French (Lille), the Swiss (Lausanne) and the Italian (Brescia) datasets.

The number of patients with dementia is estimated to increase given the aging population. This will lead to a number of challenges in the future in terms of diagnosis and care for patients with dementia. To meet these needs such as early diagnsosis and development of prognostic biomarkers, large datasets, such as the federated datasets on dementia. The EAN Dementia and cognitive disorders scientific panel can play an important role as coordinator and connecting panel members who wish to participate in e.g. consortia.