This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

This lesson breaks down the principles of Bayesian inference and how it relates to cognitive processes and functions like learning and perception. It is then explained how cognitive models can be built using Bayesian statistics in order to investigate how our brains interface with their environment. 

This lesson corresponds to slides 1-64 in the PDF below. 

Whereas the previous two lessons described the biophysical and signalling properties of individual neurons, this lesson describes properties of those units when part of larger networks. 

This lesson goes over some examples of how machine learners and computational neuroscientists go about designing and building neural network models inspired by biological brain systems. 

This lecture and tutorial focuses on measuring human functional brain networks, as well as how to account for inherent variability within those networks. 

Neuronify is an educational tool meant to create intuition for how neurons and neural networks behave. You can use it to combine neurons with different connections, just like the ones we have in our brain, and explore how changes on single cells lead to behavioral changes in important networks. Neuronify is based on an integrate-and-fire model of neurons. This is one of the simplest models of neurons that exist. It focuses on the spike timing of a neuron and ignores the details of the action potential dynamics. These neurons are modeled as simple RC circuits. When the membrane potential is above a certain threshold, a spike is generated and the voltage is reset to its resting potential. This spike then signals other neurons through its synapses.

Neuronify aims to provide a low entry point to simulation-based neuroscience.

Overview of the content for Day 1 of this course.

Best practices: the tips and tricks on how to get your Miniscope to work and how to get your experiments off the ground.

This talk delves into challenges and opportunities of Miniscope design, seeking the optimal balance between scale and function.

Attendees of this talk will learn aobut computational imaging systems and associated pipelines, as well as open-source software solutions supporting miniscope use.

This talk covers the present state and future directions of calcium imaging data analysis, particularly in the context of one-photon vs two-photon approaches. 

In this talk, results from rodent experimentation using in vivo imaging are presented, demonstrating how the monitoring of neural ensembles may reveal patterns of learning during spatial tasks.

How to start processing the raw imaging data generated with a Miniscope, including developing a usable pipeline and demoing the Minion pipeline.

The direction of miniature microscopes, including both MetaCell and other groups.

Overview of the content for Day 2 of this course.

Summary and closing remarks for this three-day course.

This lecture covers infrared LED oblique illumination for studying neuronal circuits in in vitro block-preparations of the spinal cord and brain stem.

This lecture covers the application of diffusion MRI for clinical and preclinical studies.

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

This talk covers the differences between applying HED annotation to fMRI datasets versus other neuroimaging practices, and also introduces an analysis pipeline using HED tags.