This lesson teaches users how MATLAB can be used to apply image processing techniques to identify cell bodies based on contiguity.

This tutorial demonstrates how to extract the time course of calcium activity from each clusters of neuron somata, and store the data in a MATLAB matrix.

This lesson demonstrates how to use MATLAB to implement a multivariate dimension reduction method, PCA, on time series data.

This lesson explores how researchers try to understand neural networks, particularly in the case of observing neural activity. 

This introductory lesson welcomes users to the virtual learning series, explaining some of the background behind open-source miniscopes, as well as outlining the rest of the lessons in this course. 

This lesson provides an overview of the Miniscope project, explaining the motivation behind the how and why of Miniscope development, why Miniscopes may be useful for researchers, and the differences between previous and current versions.

This lesson will go through the theory and practical techniques for implanting a GRIN lens for imaging in mice.

This lesson provides instruction on how to build a Miniscope and stream data, including an overview of the software involved.

This talks discusses data sharing in the context of dementia. It explains why data sharing in dementia is important, how data is usually shared in the field and illustrates two examples: the Netherlands Consortium Dementia cohorts and the European Platform for Neurodegenerative Diseases.

The Medical Informatics Platform (MIP) Dementia had been installed in several memory clinics across Europe allowing them to federate their real-world databases. Research open access databases had also been integrated such as ADNI (Alzheimer’s Dementia Neuroimaging Initiative), reaching a cumulative case load of more than 5,000 patients (major cognitive disorder due to Alzheimer’s disease, other major cognitive disorder, minor cognitive disorder, controls). The statistic and machine learning tools implemented in the MIP allowed researchers to conduct easily federated analyses among Italian memory clinics (Redolfi et al. 2020) and also across borders between the French (Lille), the Swiss (Lausanne) and the Italian (Brescia) datasets.

The number of patients with dementia is estimated to increase given the aging population. This will lead to a number of challenges in the future in terms of diagnosis and care for patients with dementia. To meet these needs such as early diagnsosis and development of prognostic biomarkers, large datasets, such as the federated datasets on dementia. The EAN Dementia and cognitive disorders scientific panel can play an important role as coordinator and connecting panel members who wish to participate in e.g. consortia.