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Improving Life Through Simulation

Difficulty level

The Virtual Brain (TVB) is an open-source, multi-scale, multi-modal brain simulation platform. In this lesson, you get introduced to brain simulation in general and to TVB in particular. This lesson also presents the newest approaches for clinical applications of TVB - that is, for stroke, epilepsy, brain tumors, and Alzheimer’s disease - and show how brain simulation can improve diagnostics, therapy, and understanding of neurological disease.

Topics covered in this lesson
  • Introduction to non-linear systems theory
  • Neural masses and mean field theory
  • Multi-scale brain modeling
  • Excitation and inhibition as crucial factors for brain dynamics
  • Simulation of stroke and prediction of clinical outcome
  • The virtual epileptic patient - towards improved neurosurgery in epilepsy
  • Simulation of brain tumors
  • Prediction of cognitive scores in Alzheimer’s disease by brain simulation
  • Linking molecular features of neurodegeneration with multi-scale modeling in Alzheimer’s disease
  • Improving the functionality of brain computer interfaces