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TVB Clinical Applications (Part I): Stroke Recovery & Dementia

Difficulty level

This lecture presents two recent clinical case studies using TVB: stroke recovery and dementia (due to Alzheimer’s Disease (AD)). Using a multi-scale neurophysiological model based on empirical multi-modal neuroimaging data, we show how local and global biophysical parameters characterize changes in individualized patient-specific brain dynamics, predict recovery of motor function for stroke patients, and correlate with individual differences in cognition for AD patients.

Topics covered in this lesson
  • General introduction to stroke
  • TVB simulation workflow for stroke patients
  • Structural reconstruction: “Virtual Brain Transplant”
  • Parameter space exploration and fitting
  • General introduction to dementia
  • TVB simulation workflow for patients with dementia
  • Pre-processing issues related to atrophy
  • Two-stage modeling: sub- and full-brain network model
  • Cognition predictor: model parameters vs. metrics of neuroimaging data