This book was written with the goal of introducing researchers and students in a variety of research fields to the intersection of data science and neuroimaging. This book reflects our own experience of doing research at the intersection of data science and neuroimaging and it is based on our experience working with students and collaborators who come from a variety of backgrounds and have a variety of reasons for wanting to use data science approaches in their work. The tools and ideas that we chose to write about are all tools and ideas that we have used in some way in our own research. Many of them are tools that we use on a daily basis in our work. This was important to us for a few reasons: the first is that we want to teach people things that we ourselves find useful. Second, it allowed us to write the book with a focus on solving specific analysis tasks. For example, in many of the chapters you will see that we walk you through ideas while implementing them in code, and with data. We believe that this is a good way to learn about data analysis, because it provides a connecting thread from scientific questions through the data and its representation to implementing specific answers to these questions. Finally, we find these ideas compelling and fruitful. That’s why we were drawn to them in the first place. We hope that our enthusiasm about the ideas and tools described in this book will be infectious enough to convince the readers of their value.

This lesson provides an overview of the current status in the field of neuroscientific ontologies, presenting examples of data organization and standards, particularly from neuroimaging and electrophysiology. 

Following the previous lesson on neuronal structure, this lesson discusses neuronal function, particularly focusing on spike triggering and propogation. 

This lesson introduces the practical exercises which accompany the previous lessons on animal and human connectomes in the brain and nervous system. 

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

This lesson provides an introduction to the myriad forms of cellular mechanisms whicn underpin healthy brain function and communication. 

This lesson provides an introduction to the course Cellular Mechanisms of Brain Function.

In this lesson you will learn about ion channels and the movement of ions across the cell membrane, one of the key mechanisms underlying neuronal communication. 

This lesson presents the typical setup, equipment, and solutions used in whole-cell recording of neurons. 

This lesson provides an introductory overview to synaptic transmission and associated neurotransmitters. 

This lecture covers NeuronUnit, a library that builds upon SciUnit and integrates with several existing neuroinformatics resources to support validating single-neuron models using data gathered by neurophysiologists.

This lesson provides an introduction to the NeuroElectro project, which aims to organize information on cellular neurophysiology.

This lesson covers simultaneously recorded neurons in non-human primates coordinate their spiking activity in a sequential manner that mirrors the dominant wave propagation directions of the local field potentials.

This talk covers statistical analysis of spike train data, the modeling approach GLM, and the problem of assessing neural synchrony.

This talk covers statistical methods for characterizing neural population responses and extracting structure from high-dimensional neural data.

This presentation discusses research aimed at understanding the activity of single neurons and populations of neurons in the visual system.

Neurodata Without Borders (NWB) is a data standard for neurophysiology that provides neuroscientists with a common standard to share, archive, use, and build common analysis tools for neurophysiology data.

This lesson provides a brief introduction to the Neuroscience Information Exchange (NIX) Format data model, which allows storing fully annotated scientific datasets, i.e., data combined with rich metadata and their relations in a consistent, comprehensive format.

In this lecture, attendees will learn how Mutant Mouse Resource and Research Center (MMRRC) archives, cryopreserves, and distributes scientifically valuable genetically engineered mouse strains and mouse ES cell lines for the genetics and biomedical research community.

This lesson provides an overview of Neurodata Without Borders (NWB), an ecosystem for neurophysiology data standardization. The lecture also introduces some NWB-enabled tools.