The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

This lecture introduces neuroscience concepts and methods such as fMRI, visual respones in BOLD data, and the eccentricity of visual receptive fields. 

In this tutorial, users learn how to compute and visualize a t-test on experimental condition differences.

This lesson continues with the second workshop on reproducible science, focusing on additional open source tools for researchers and data scientists, such as the R programming language for data science, as well as associated tools like RStudio and R Markdown. Additionally, users are introduced to Python and iPython notebooks, Google Colab, and are given hands-on tutorials on how to create a Binder environment, as well as various containers in Docker and Singularity.

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics. 

This video will document how to run a correlation analysis between the gray matter volume of two different structures using the output from brainlife app-freesurfer-stats.

As the previous lesson of this course described how researchers acquire neural data, this lesson will discuss how to go about interpreting and analysing the data. 

In this lesson, you will learn about one particular aspect of decision making: reaction times. In other words, how long does it take to take a decision based on a stream of information arriving continuously over time?

The state of the field regarding the diagnosis and treatment of major depressive disorder (MDD) is discussed. Current challenges and opportunities facing the research and clinical communities are outlined, including appropriate quantitative and qualitative analyses of the heterogeneity of biological, social, and psychiatric factors which may contribute to MDD.

This lesson delves into the opportunities and challenges of telepsychiatry. While novel digital approaches to clinical research and care have the potential to improve and accelerate patient outcomes, researchers and care providers must consider new population factors, such as digital disparity. 

This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.

This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis, and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.

This lecture will provide an overview of neuroimaging techniques and their clinical applications.

This lecture picks up from the previous lesson, providing an overview of neuroimaging techniques and their clinical applications.

This lesson discusses both state-of-the-art detection and prevention schema in working with neurodegenerative diseases. 

This lecture provides an overview of depression (epidemiology and course of the disorder), clinical presentation, somatic co-morbidity, and treatment options.

In this lesson, you will learn about how genetics can contribute to our understanding of psychiatric phenotypes.

This lecture focuses on the rationale for employing neuroimaging methods for movement disorders.

This lecture provides an overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the central nervous system. 

This lecture covers the rationale for developing the DAQCORD, a framework for the design, documentation, and reporting of data curation methods in order to advance the scientific rigour, reproducibility, and analysis of data.