Skip to main content

Navigating the rodent brain by digital atlasing

Difficulty level

This lecture highlights the importance of correct annotation and assignment of location, and updated atlas resources to avoid errors in navigation and data interpretation.

Topics covered in this lesson
  • Talk abstract: Accurate assignment of anatomical location to rat and mouse brain image data is essential for interpretation and comparison of experimental measurements. Rodent brain atlases therefore rank among the most cited neuroscience publications. New generation open-access atlases now provide volumetric reference templates based on high-resolution MRI data, and recent studies have shown that anatomical regions and subregions to a large extent can be defined on the basis of MRI contrast. Volumetric atlas templates will allow researchers to efficiently accumulate, analyze, compare, and reuse experimental data. But before these promising resources can fulfil their potential, efficient tools and procedures for data registration are needed, and important concerns regarding anatomical precision must be considered. I will here review recent developments in the field of digital atlasing and discuss some challenges ahead.