Modelling across scales of analysis
Forms of plasticity on many levels - short-term, long-term, metaplasticity, structural plasticity. With examples related to modelling of biochemical networks.
[NB: The sound uptake is a bit noisy the first few minutes, but gets better from about 5 mins in]
Topics covered in this lesson
- Forms of plasticity. Is memory the same as synaptic plasticity? Hebb rule.
- Pavlovian (classical) conditioning.
- NMDA receptor role in associativity.
- Synaptic weight/strength.
- Network computation.
- Associative memory.
- Pattern recognition and completion.
- Feedback and bistability.
- Switches and logic in Pavlovian conditioning.
- Plasticity dependent on input patterns.
- Equation for synaptic weight.
- Dendritic protein synthesis.
- Bistability. Metaplasticity.
- Structural plasticity.
- Interacting switches and long-term stability.
- Molecules involved in bistability.
This presentation assumes some familiarity with biochemical networks involved in synaptic plasticity and some knowledge of biochemical network modelling and simulation. Recommended: Cellular Mechanisms of Brain Function, especially lectures 13 on pre-synaptic plasticity and lectures 16-20 on post-synaptic plasticity.