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Modelling Across Scales of Analysis

Difficulty level

This lesson provides an overview of plasticity on many levels, including short-term, long-term, metaplasticity, and structural plasticity. The lesson also provides xamples related to modelling of biochemical networks. 

Note: The sound uptake is a bit noisy the first few minutes, but gets better from about 5 mins in

Topics covered in this lesson
  • Forms of plasticity. Is memory the same as synaptic plasticity? Hebb rule.
  • Pavlovian (classical) conditioning.
  • NMDA receptor role in associativity.
  • Synaptic weight/strength.
  • Network computation.
  • Associative memory.
  • Pattern recognition and completion.
  • Feedback and bistability.
  • Switches and logic in Pavlovian conditioning.
  • Plasticity dependent on input patterns.
  • Equation for synaptic weight.
  • Facilitation/depression.
  • Dendritic protein synthesis.
  • Bistability. Metaplasticity.
  • Structural plasticity.
  • Interacting switches and long-term stability.
  • Molecules involved in bistability.

This presentation assumes some familiarity with biochemical networks involved in synaptic plasticity and some knowledge of biochemical network modelling and simulation. Recommended: Cellular Mechanisms of Brain Function, especially lectures 13 on pre-synaptic plasticity and lectures 16-20 on post-synaptic plasticity.