With a new generation of three-dimensional digital reference atlases, new solutions for integrating and disseminating brain data are being developed. Digital brain atlases play an important role in several large international projects, including the European Union ICT Future Emerging Technologies Flagship project, the Human Brain Project.This course contains an introduction to currently available reference atlases for mouse and rat brain. It will demonstrate how the 3D brain templates for the reference atlases are acquired, how they are used as a basis for delineating the structures of the brain, how they can be enriched by other data modalities, and how they can be used as a basis for assigning location (coordinate based or semantic) to a wide range of structural and functional data collected from the brain. The course will also outline examples of data system employed to organize neuroscience data collections in the context of reference atlases as well as analytical workflows applied to the data, with opportunities for hands-on exploration of selected tools.
Neuroscience Data Integration Through Use of Digital Brain Atlases
This lesson provides an introduction to the course Neuroscience Data Integration Through Use of Digital Brain Atlases, during which attendees will learn about concepts for integration of research data, approaches and resources for assigning anatomical location to brain data, and infrastructure for sharing experimental brain research data.
This talk covers the various concepts, motivations, and trends within the neuroscientific community related to the sharing and integration of brain research data.
This lesson focuses on the neuroanatomy of the human brain, delving into macrostructures like cortices, lobes, and hemispheres, and microstructures like neurons and cortical laminae.
This lesson provides an introduction to the European open research infrastructure EBRAINS and its digital brain atlas resources.
In this lesson, attendees will learn about the challenges in assigning experimental brain data to specific locations, as well as the advantages and shortcomings of current location assignment procedures.
This lesson covers the inherent difficulties associated with integrating neuroscientific data, as well as the current methods and approaches to do so.
Attendees of this talk will learn about QuickNII, a tool for user-guided affine registration of 2D experimental image data to 3D atlas reference spaces, which also facilitates data integration through standardized coordinate systems.
This lesson provides an overview of DeepSlice, a Python package which aligns histology to the Allen Brain Atlas and Waxholm Rat Atlas using deep learning.
This short talk addresses how to use VisuAlign to make nonlinear adjustments to 2D-to-3D registrations generated by QuickNII.
This talk aims to provide guidance regarding the myriad labelling methods for histological image data.
This lesson provides a cross-species comparison of neuron types in the rat and mouse brain.
This lecture concludes the course with an outline of future directions of the field of neuroscientific research data integration.