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Structure of Synapses

Difficulty level

In this lesson you will learn about investigating the structure of synapses with electron microscopy. 

Topics covered in this lesson
  • Imaging neuronal structure with electron microscopy
  • Considerations for electron microscopy of biological structures
  • Preparing samples for electron microscopy
  • Chemical fixation
  • Mechanism of action of aldehydes
  • Staining and embedding brain tissue for electron microscopy
  • Post staining of ultra-thin sections
  • Transmission electron microscope
  • Scanning electron microscope
  • Sequential imaging
  • Block face scanning electron microscopy
  • Synaptic ultrastructure