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Simulating the Long Time Scales and Large Molecule Numbers Involved in Synaptic Plasticity

By
Difficulty level
Advanced
Type
Duration
15:44

In this lesson you will hear about several computationally demanding studies of synaptic plasticity on the molecular level.

Topics covered in this lesson
  • Long-term synaptic plasticity.
  • Spatial specificity and information processing in dendrites/spines.
  • Stochastic reactions and diffusion.
  • Tau leap algorithm.
  • Temporal specificity.
  • Depolarization induced suppression of inhibition.
  • Simulation results in a high-resolution compartmental model of a dendrite with spines.
Prerequisites

This presentation requires familiarity with biochemical networks involved in synaptic plasticity and some knowledge of biochemical network modelling and simulation. Recommended: Cellular Mechanisms of Brain Function, especially lectures 16-20 on post-synaptic plasticity.