Modelling Across Scales of Analysis
This lesson discuses forms of neural plasticity on many levels, including short-term, long-term, metaplasticity, and structural plasticity. During the lesson you will also be presented with examples related to the modelling of biochemical networks.
- Forms of plasticity. Is memory the same as synaptic plasticity? Hebb rule.
- Pavlovian (classical) conditioning.
- NMDA receptor role in associativity.
- Synaptic weight/strength.
- Network computation.
- Associative memory.
- Pattern recognition and completion.
- Feedback and bistability.
- Plasticity dependent on input patterns.
- Equation for synaptic weight.
- Dendritic protein synthesis.
- Bistability. Metaplasticity.
This presentation assumes some familiarity with biochemical networks involved in synaptic plasticity and some knowledge of biochemical network modelling and simulation. Recommended: Cellular Mechanisms of Brain Function, especially lectures 13 on pre-synaptic plasticity and lectures 16-20 on post-synaptic plasticity.