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Explore how to setup an epileptic seizure simulation with the TVB graphical user interface. This lesson will show you how to program the epileptor model in the brain network to simulate a epileptic seizure originating in the hippocampus. It will also show how to upload and view mouse connectivity data, as well as give a short introduction to the python script interface of TVB.

Difficulty level: Intermediate
Duration: 58:06
Speaker: : Paul Triebkorn

In this lesson you will learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper On the Nature of Seizure Dynamics, which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

Difficulty level: Beginner
Duration: 4:44
Speaker: : Paul Triebkorn
Course:

The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

Difficulty level: Beginner
Duration: 55:36
Speaker: : Elissa Chesler

This lesson provides a brief introduction to the Computational Modeling of Neuronal Plasticity.

Difficulty level: Intermediate
Duration: 0:40

In this lesson, you will be introducted to a type of neuronal model known as the leaky integrate-and-fire (LIF) model.

Difficulty level: Intermediate
Duration: 1:23

This lesson goes over various potential inputs to neuronal synapses, loci of neural communication.

Difficulty level: Intermediate
Duration: 1:20

This lesson describes the how and why behind implementing integration time steps as part of a neuronal model.

Difficulty level: Intermediate
Duration: 1:08

In this lesson, you will learn about neural spike trains which can be characterized as having a Poisson distribution.

Difficulty level: Intermediate
Duration: 1:18

This lesson covers spike-rate adaptation, the process by which a neuron's firing pattern decays to a low, steady-state frequency during the sustained encoding of a stimulus.

Difficulty level: Intermediate
Duration: 1:26

This lesson provides a brief explanation of how to implement a neuron's refractory period in a computational model.

Difficulty level: Intermediate
Duration: 0:42

In this lesson, you will learn a computational description of the process which tunes neuronal connectivity strength, spike-timing-dependent plasticity (STDP).

Difficulty level: Intermediate
Duration: 2:40

This lesson reviews theoretical and mathematical descriptions of correlated spike trains.

Difficulty level: Intermediate
Duration: 2:54

This lesson investigates the effect of correlated spike trains on spike-timing dependent plasticity (STDP).

Difficulty level: Intermediate
Duration: 1:43

This lesson goes over synaptic normalisation, the homeostatic process by which groups of weighted inputs scale up or down their biases.

Difficulty level: Intermediate
Duration: 2:58

In this lesson, you will learn about the intrinsic plasticity of single neurons.

Difficulty level: Intermediate
Duration: 2:08

This lesson covers short-term facilitation, a process whereby a neuron's synaptic transmission is enhanced for a short (sub-second) period.

Difficulty level: Intermediate
Duration: 1:58

This lesson describes short-term depression, a reduction of synaptic information transfer between neurons.

Difficulty level: Intermediate
Duration: 1:40

This lesson briefly wraps up the course on Computational Modeling of Neuronal Plasticity.

Difficulty level: Intermediate
Duration: 0:37

This lesson is the first of three hands-on tutorials as part of the workshop Research Workflows for Collaborative Neuroscience. This tutorial goes over how to visualize data with Scanpy, a scalable toolkit for analyzing single-cell gene expression. 

Difficulty level: Intermediate
Duration: 25:26

This hands-on tutorial walks you through DataJoint platform, highlighting features and schema which can be used to build robost neuroscientific pipelines. 

Difficulty level: Beginner
Duration: 26:06
Speaker: : Milagros Marin