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The simulation of the virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved results in clinics. The fundamentals of epilepsy are explained. On this basis, the concept of epilepsy simulation is developed. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

Difficulty level: Beginner
Duration: 1:28:53
Speaker: : Julie Courtiol

Learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper: On the Nature of Seizure Dynamics which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

Difficulty level: Beginner
Duration: 4:44
Speaker: : Paul Triebkorn
Course:

The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

Difficulty level: Beginner
Duration: 55:36
Speaker: : Elissa Chesler
Difficulty level: Beginner
Duration: 43:38
Speaker: : Kent Lloyd

Tutorial describing the basic search and navigation features of the Allen Mouse Brain Atlas

Difficulty level: Beginner
Duration: 6:40
Speaker: : Unknown

Tutorial describing the basic search and navigation features of the Allen Developing Mouse Brain Atlas

Difficulty level: Beginner
Duration: 6:35
Speaker: : Unknown

Tutorial describing the basic features of the Brain Explorer® 3-D viewer for the mouse brain

Difficulty level: Beginner
Duration: 6:41
Speaker: : Unknown

This tutorial demonstrates how to use the differential search feature of the Allen Mouse Brain Atlas to find gene markers for different regions of the brain and to visualize this gene expression in three-dimensional space. Differential search is also available for the Allen Developing Mouse Brain Atlas and the Allen Human Brain Atlas.

Difficulty level: Beginner
Duration: 6:31
Speaker: : Unknown

The chair of the workshop is giving an introduction and a motivating argument.

Difficulty level: Beginner
Duration: 5:36
Speaker: : Maryann Martone

Introductory presentation on how data science can help with scientific reproducibility.

Difficulty level: Beginner
Duration:
Speaker: : Michel Dumontier

Ion channels and the movement of ions across the cell membrane.

Difficulty level: Beginner
Duration: 28:08
Speaker: : Carl Petersen

Action potentials, and biophysics of voltage-gated ion channels.

Difficulty level: Beginner
Duration: 27:47
Speaker: : Carl Petersen

Voltage-gating kinetics of sodium and potassium channels.

Difficulty level: Beginner
Duration: 19:20
Speaker: : Carl Petersen

The ionic basis of the action potential, including the Hodgkin Huxley model.

Difficulty level: Beginner
Duration: 28:29
Speaker: : Carl Petersen

Action potential initiation and propagation.

Difficulty level: Beginner
Duration: 23:16
Speaker: : Carl Petersen

Long-range inhibitory connections in the brain, with examples from three different systems.

Difficulty level: Beginner
Duration: 19:05
Speaker: : Carl Petersen

How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.

Difficulty level: Beginner
Duration: 1:08:45
Speaker: : Clay Reid

Introduction to neurons, synaptic transmission, and ion channels.

Difficulty level: Beginner
Duration: 46:07

2nd part of the lecture. Introduction to cell receptors and signalling cascades

Difficulty level: Beginner
Duration: 41:38

Introduction to the types of glial cells, homeostasis (influence of cerebral blood flow and influence on neurons), insulation and protection of axons (myelin sheath; nodes of Ranvier), microglia and reactions of the CNS to injury.

Difficulty level: Beginner
Duration: 40:32