This lecture gives an introduction to the types of glial cells, homeostasis (influence of cerebral blood flow and influence on neurons), insulation and protection of axons (myelin sheath; nodes of Ranvier), microglia and reactions of the CNS to injury.
This lesson discusses both state-of-the-art detection and prevention schema in working with neurodegenerative diseases.
This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis, and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
This lecture provides an introduction to the study of eye-tracking in humans.
From the retina to the superior colliculus, the lateral geniculate nucleus into primary visual cortex and beyond, this lecture gives a tour of the mammalian visual system highlighting the Nobel-prize winning discoveries of Hubel & Wiesel.
From Universal Turing Machines to McCulloch-Pitts and Hopfield associative memory networks, this lecture explains what is meant by computation.
In an overview of the structure of the mammalian neocortex, this lecture explains how the mammalian cortex is organized in a hierarchy, describing the columnar principle and canonical microcircuits.
The retina has 60 different types of neurons. What are their functions? This lecture explores the definition of cell types and their functions in the mammalian retina.
Optical imaging offers a look inside the working brain. This lecture takes a look at orientation and ocular dominance columns in the visual cortex, and shows how they can be viewed with calcium imaging.
Functional imaging has led to the discovery of a plethora of visual cortical regions. This lecture introduces functional imaging techniques and their teachings about the visual cortex.
This lecture explains these ideas and explores the task of characterizing neuronal response properties using information theory.
What is color? This lecture explores how color is "made" in the brain and variations of color perception including trichromacy, color blindness in men, tetrachromatic vision in women, and genetic engineering of color perception.
How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.
What is the difference between attention and consciousness? This lecture describes the scientific meaning of consciousness, journeys on the search for neural correlates of visual consciousness, and explores the possibility of consciousness in other beings and even non-biological structures.
This primer on optogenetics primer discusses how to manipulate neuronal populations with light at millisecond resolution and offers possible applications such as curing the blind and "playing the piano" with cortical neurons.
This lecture provides an introduction to the application of genetic testing in neurodevelopmental disorders.
This lesson describes the fundamentals of genomics, from central dogma to design and implementation of GWAS, to the computation, analysis, and interpretation of polygenic risk scores.
This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics.
This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.
This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes.