This book was written with the goal of introducing researchers and students in a variety of research fields to the intersection of data science and neuroimaging. This book reflects our own experience of doing research at the intersection of data science and neuroimaging and it is based on our experience working with students and collaborators who come from a variety of backgrounds and have a variety of reasons for wanting to use data science approaches in their work. The tools and ideas that we chose to write about are all tools and ideas that we have used in some way in our own research. Many of them are tools that we use on a daily basis in our work. This was important to us for a few reasons: the first is that we want to teach people things that we ourselves find useful. Second, it allowed us to write the book with a focus on solving specific analysis tasks. For example, in many of the chapters you will see that we walk you through ideas while implementing them in code, and with data. We believe that this is a good way to learn about data analysis, because it provides a connecting thread from scientific questions through the data and its representation to implementing specific answers to these questions. Finally, we find these ideas compelling and fruitful. That’s why we were drawn to them in the first place. We hope that our enthusiasm about the ideas and tools described in this book will be infectious enough to convince the readers of their value.
This tutorial introduces pipelines and methods to compute brain connectomes from fMRI data. With corresponding code and repositories, participants can follow along and learn how to programmatically preprocess, curate, and analyze functional and structural brain data to produce connectivity matrices.
This lesson introduces the practical exercises which accompany the previous lessons on animal and human connectomes in the brain and nervous system.
This lecture and tutorial focuses on measuring human functional brain networks, as well as how to account for inherent variability within those networks.
This lesson provides a brief introduction to the Computational Modeling of Neuronal Plasticity.
In this lesson, you will be introducted to a type of neuronal model known as the leaky integrate-and-fire (LIF) model.
This lesson goes over various potential inputs to neuronal synapses, loci of neural communication.
This lesson describes the how and why behind implementing integration time steps as part of a neuronal model.
In this lesson, you will learn about neural spike trains which can be characterized as having a Poisson distribution.
This lesson covers spike-rate adaptation, the process by which a neuron's firing pattern decays to a low, steady-state frequency during the sustained encoding of a stimulus.
This lesson provides a brief explanation of how to implement a neuron's refractory period in a computational model.
In this lesson, you will learn a computational description of the process which tunes neuronal connectivity strength, spike-timing-dependent plasticity (STDP).
This lesson reviews theoretical and mathematical descriptions of correlated spike trains.
This lesson investigates the effect of correlated spike trains on spike-timing dependent plasticity (STDP).
This lesson goes over synaptic normalisation, the homeostatic process by which groups of weighted inputs scale up or down their biases.
In this lesson, you will learn about the intrinsic plasticity of single neurons.
This lesson covers short-term facilitation, a process whereby a neuron's synaptic transmission is enhanced for a short (sub-second) period.
This lesson describes short-term depression, a reduction of synaptic information transfer between neurons.
This lesson briefly wraps up the course on Computational Modeling of Neuronal Plasticity.
This tutorial provides instruction on how to simulate brain tumors with TVB (reproducing publication: Marinazzo et al. 2020 Neuroimage). This tutorial comprises a didactic video, jupyter notebooks, and full data set for the construction of virtual brains from patients and health controls.