This talk gives an overview of the Human Brain Project, a 10-year endeavour putting in place a cutting-edge research infrastructure that will allow scientific and industrial researchers to advance our knowledge in the fields of neuroscience, computing, and brain-related medicine.
This lecture gives an introduction to the European Academy of Neurology, its recent achievements and ambitions.
This lecture presents the Medical Informatics Platform's data federation in epilepsy.
This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.
This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics.
This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.
This lesson breaks down the principles of Bayesian inference and how it relates to cognitive processes and functions like learning and perception. It is then explained how cognitive models can be built using Bayesian statistics in order to investigate how our brains interface with their environment.
This lesson corresponds to slides 1-64 in the PDF below.
This lecture aims to help researchers, students, and health care professionals understand the place for neuroinformatics in the patient journey using the exemplar of an epilepsy patient.
This lesson continues from part one of the lecture Ontologies, Databases, and Standards, diving deeper into a description of ontologies and knowledg graphs.
In this final lecture of the INCF Short Course: Introduction to Neuroinformatics, you will hear about new advances in the application of machine learning methods to clinical neuroscience data. In particular, this talk discusses the performance of SynthSeg, an image segmentation tool for automated analysis of highly heterogeneous brain MRI clinical scans.
This lesson characterizes different types of learning in a neuroscientific and cellular context, and various models employed by researchers to investigate the mechanisms involved.
In this lesson, you will learn about different approaches to modeling learning in neural networks, particularly focusing on system parameters such as firing rates and synaptic weights impact a network.
This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page.
In this lesson, you will learn about some of the many methods to train spiking neural networks (SNNs) with either no attempt to use gradients, or only use gradients in a limited or constrained way.
In this lesson, you will learn how to train spiking neural networks (SNNs) with a surrogate gradient method.
In this lesson, you will hear about some of the open issues in the field of neuroscience, as well as a discussion about whether neuroscience works, and how can we know?
Explore how to setup an epileptic seizure simulation with the TVB graphical user interface. This lesson will show you how to program the epileptor model in the brain network to simulate a epileptic seizure originating in the hippocampus. It will also show how to upload and view mouse connectivity data, as well as give a short introduction to the python script interface of TVB.
Brain network reconstruction from empirical data is of key importance to generate personalized virtual brain models. This lecture will introduce the basic concepts of preprocessing structural, functional and diffusion weighted neuroimages. It highlights the latest methods and pipelines to extract structural as well as functional connectomes according to a multimodal parcellation.
Along the example of a patient with bi-temporal epilepsy, we show step by step how to develop a Virtual Epileptic Patient (VEP) brain model and integrate patient-specific information such as brain connectivity, epileptogenic zone and MRI lesions. The patient's brain network model is then evaluated via simulation, data fitting and mathematical analysis. This lecture demonstrates how to develop novel personalized strategies towards therapy and intervention using TVB.
This lecture focuses on higher-level simulation scenarios using stimulation protocols. We demonstrate how to build stimulation patterns in TVB, and use them in a simulation to induced activity dissipating into experimentally known resting-state networks in human and mouse brain, a well as to obtain EEG recordings reproducing empirical findings of other researchers.