This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.
This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.
This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health.
This lecture goes into detailed description of how to process workflows in the virtual research environment (VRE), including approaches for standardization, metadata, containerization, and constructing and maintaining scientific pipelines.
This lesson briefly goes over the outline of the Neuroscience for Machine Learners course.
Following the previous lesson on neuronal structure, this lesson discusses neuronal function, particularly focusing on spike triggering and propogation.
This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted.
While the previous lesson in the Neuro4ML course dealt with the mechanisms involved in individual synapses, this lesson discusses how synapses and their neurons' firing patterns may change over time.
As the previous lesson of this course described how researchers acquire neural data, this lesson will discuss how to go about interpreting and analysing the data.
In this lesson you will learn about the motivation behind manipulating neural activity, and what forms that may take in various experimental designs.
In this lesson, you will learn about one particular aspect of decision making: reaction times. In other words, how long does it take to take a decision based on a stream of information arriving continuously over time?
In this lesson, you will learn in more detail about neuromorphic computing, that is, non-standard computational architectures that mimic some aspect of the way the brain works.
This video provides a very quick introduction to some of the neuromorphic sensing devices, and how they offer unique, low-power applications.
In this lesson, you will hear about some of the open issues in the field of neuroscience, as well as a discussion about whether neuroscience works, and how can we know?
This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication?
This lecture introduces you to the basics of the Amazon Web Services public cloud. It covers the fundamentals of cloud computing and goes through both the motivations and processes involved in moving your research computing to the cloud.
This lecture provides an introduction to entropy in general, and multi-scale entropy (MSE) in particular, highlighting the potential clinical applications of the latter.
This lecture provides an general introduction to epilepsy, as well as why and how TVB can prove useful in building and testing epileptic models.
This lecture covers the rationale for developing the DAQCORD, a framework for the design, documentation, and reporting of data curation methods in order to advance the scientific rigour, reproducibility, and analysis of data.
In this session the Medical Informatics Platform (MIP) federated analytics is presented. The current and future analytical tools implemented in the MIP will be detailed along with the constructs, tools, processes, and restrictions that formulate the solution provided. MIP is a platform providing advanced federated analytics for diagnosis and research in clinical neuroscience research. It is targeting clinicians, clinical scientists and clinical data scientists. It is designed to help adopt advanced analytics, explore harmonized medical data of neuroimaging, neurophysiological and medical records as well as research cohort datasets, without transferring original clinical data. It can be perceived as a virtual database that seamlessly presents aggregated data from distributed sources, provides access and analyze imaging and clinical data, securely stored in hospitals, research archives and public databases. It leverages and re-uses decentralized patient data and research cohort datasets, without transferring original data. Integrated statistical analysis tools and machine learning algorithms are exposed over harmonized, federated medical data.