This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

While the previous lesson in the Neuro4ML course dealt with the mechanisms involved in individual synapses, this lesson discusses how synapses and their neurons' firing patterns may change over time. 

This lesson introduces the practical exercises which accompany the previous lessons on animal and human connectomes in the brain and nervous system. 

This lesson explores how researchers try to understand neural networks, particularly in the case of observing neural activity. 

In this lesson, you will learn about one particular aspect of decision making: reaction times. In other words, how long does it take to take a decision based on a stream of information arriving continuously over time?

In this lesson, you will learn in more detail about neuromorphic computing, that is, non-standard computational architectures that mimic some aspect of the way the brain works. 

This video provides a very quick introduction to some of the neuromorphic sensing devices, and how they offer unique, low-power applications.

This lecture provides an introduction to the Brain Imaging Data Structure (BIDS), a standard for organizing human neuroimaging datasets.

Learn how to create a standard extracellular electrophysiology dataset in NWB using Python.

Learn how to create a standard calcium imaging dataset in NWB using Python.

In this tutorial, you will learn how to create a standard intracellular electrophysiology dataset in NWB using Python.

Learn how to create a standard intracellular electrophysiology dataset in NWB.

This book was written with the goal of introducing researchers and students in a variety of research fields to the intersection of data science and neuroimaging. This book reflects our own experience of doing research at the intersection of data science and neuroimaging and it is based on our experience working with students and collaborators who come from a variety of backgrounds and have a variety of reasons for wanting to use data science approaches in their work. The tools and ideas that we chose to write about are all tools and ideas that we have used in some way in our own research. Many of them are tools that we use on a daily basis in our work. This was important to us for a few reasons: the first is that we want to teach people things that we ourselves find useful. Second, it allowed us to write the book with a focus on solving specific analysis tasks. For example, in many of the chapters you will see that we walk you through ideas while implementing them in code, and with data. We believe that this is a good way to learn about data analysis, because it provides a connecting thread from scientific questions through the data and its representation to implementing specific answers to these questions. Finally, we find these ideas compelling and fruitful. That’s why we were drawn to them in the first place. We hope that our enthusiasm about the ideas and tools described in this book will be infectious enough to convince the readers of their value.

This Jupyter Book is a series of interactive tutorials about quantitative T1 mapping, powered by qMRLab. Most figures are generated with Plot.ly – you can play with them by hovering your mouse over the data, zooming in (click and drag) and out (double click), moving the sliders, and changing the drop-down options. To view the code that was used to generate the figures in this blog post, hover your cursor in the top left corner of the frame that contains the tutorial and click the checkbox “All cells” in the popup that appears.

Jupyter Lab notebooks of these tutorials are also available through MyBinder, and inline code modification inside the Jupyter Book is provided by Thebelab. For both options, you can modify the code, change the figures, and regenerate the html that was used to create the tutorial below. This Jupyter Book also uses a Script of Scripts (SoS) kernel, allowing us to process the data using qMRLab in MATLAB/Octave and plot the figures with Plot.ly using Python, all within the same Jupyter Notebook.