Neuronify is an educational tool meant to create intuition for how neurons and neural networks behave. You can use it to combine neurons with different connections, just like the ones we have in our brain, and explore how changes on single cells lead to behavioral changes in important networks. Neuronify is based on an integrate-and-fire model of neurons. This is one of the simplest models of neurons that exist. It focuses on the spike timing of a neuron and ignores the details of the action potential dynamics. These neurons are modeled as simple RC circuits. When the membrane potential is above a certain threshold, a spike is generated and the voltage is reset to its resting potential. This spike then signals other neurons through its synapses.
Neuronify aims to provide a low entry point to simulation-based neuroscience.
This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
This lecture will provide an overview of neuroimaging techniques and their clinical applications.
This lecture will provide an overview of neuroimaging techniques and their clinical applications
This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases
This lecture provides an overview of depression (epidemiology and course of the disorder), clinical presentation, somatic co-morbidity, and treatment options.
How genetics can contribute to our understanding of psychiatric phenotypes.
The lecture focuses on rationale for employing neuroimaging methods for movement disorders
An overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the Central Nervous System.
Longitudinal Online Research and Imaging System (LORIS) is a web-based data and project management software for neuroimaging research studies. It is an open source framework for storing and processing behavioural, clinical, neuroimaging and genetic data. LORIS also makes it easy to manage large datasets acquired over time in a longitudinal study, or at different locations in a large multi-site study.
DAQCORD is a framework for the design, documentation and reporting of data curation methods in order to advance the scientific rigour, reproducibility and analysis of the data. This lecture covers the rationale for developing the framework, the process in which the framework was developed, and ends with a presentation of the framework. While the driving use case for DAQCORD was clinical traumatic brain injury research, the framework is applicable to clinical studies in other domains of clinical neuroscience research.
The Medical Informatics Platform (MIP) is a platform providing federated analytics for diagnosis and research in clinical neuroscience research. The federated analytics is possible thanks to a distributed engine that executes computations and transfers information between the members of the federation (hospital nodes). In this talk the speaker will describe the process of designing and implementing new analytical tools, i.e. statistical and machine learning algorithms. Mr. Sakellariou will further describe the environment in which these federated algorithms run, the challenges and the available tools, the principles that guide its design and the followed general methodology for each new algorithm. One of the most important challenges which are faced is to design these tools in a way that does not compromise the privacy of the clinical data involved. The speaker will show how to address the main questions when designing such algorithms: how to decompose and distribute the computations and what kind of information to exchange between nodes, in order to comply with the privacy constraint mentioned above. Finally, also the subject of validating these federated algorithms will be briefly touched.
The goal of this module is to work with action potential data taken from a publicly available database. You will learn about spike counts, orientation tuning, and spatial maps. The MATLAB code introduces data types, for-loops and vectorizations, indexing, and data visualization.
The goal of this module is to work with action potential data taken from a publicly available database. You will learn about spike counts, orientation tuning, and spatial maps. The MATLAB code introduces data types, for-loops and vectorizations, indexing, and data visualization.
The goal of this module is to work with action potential data taken from a publicly available database. You will learn about spike counts, orientation tuning, and spatial maps. The MATLAB code introduces data types, for-loops and vectorizations, indexing, and data visualization.
The goal of this module is to work with action potential data taken from a publicly available database. You will learn about spike counts, orientation tuning, and spatial maps. The MATLAB code introduces data types, for-loops and vectorizations, indexing, and data visualization.
The goal of this module is to work with action potential data taken from a publicly available database. You will learn about spike counts, orientation tuning, and spatial maps. The MATLAB code introduces data types, for-loops and vectorizations, indexing, and data visualization.
KnowledgeSpace is a community-based encyclopedia that links brain research concepts to data, models, and literature. It provides users with access to anatomy, gene expression, models, morphology, and physiology data from over 15 different neuroscience data/model repositories, such as Allen Institute for Brain Science and the Human Brain Project.
This module explores sensation in the brain: what organs are involved, sensory pathways, processing centers, and theories of integration. We cover sensory transduction, vision, audition olfaction, gustation, and somatosensation.