The simulation of the virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved results in clinics. The fundamentals of epilepsy are explained. On this basis, the concept of epilepsy simulation is developed. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

Explore how to setup an epileptic seizure simulation with the TVB graphical user interface. This lesson will show you how to program the epileptor model in the brain network to simulate a epileptic seizure originating in the hippocampus. It will also show how to upload and view mouse connectivity data, as well as give a short introduction to the python script interface of TVB.

Learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper: On the Nature of Seizure Dynamics which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity.

This lecture covers an introduction to neuroinformatics and its subfields, the content of the short course and future neuroinformatics applications.

This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Introduction to the course Cellular Mechanisms of Brain Function.

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Introduction to the course Cellular Mechanisms of Brain Function.

Ion channels and the movement of ions across the cell membrane.

Spatiotemporal dynamics of the membrane potential.

Action potentials, and biophysics of voltage-gated ion channels.

Voltage-gating kinetics of sodium and potassium channels.

The ionic basis of the action potential, including the Hodgkin Huxley model.

Action potential initiation and propagation.

Neurotransmitter release in the presynaptic specialization.

Synaptic modulation through diffusing neurotransmitters.

Glutamatergic transmission.

Glutamate release after an action potential. Resulting post-synaptic potentials in a biophysically realistic situation.