This lecture covers computational principles that growth cones employ to detect and respond to environmental chemotactic gradients, focusing particularly on growth-cone shape dynamics.

In this lecture you will learn that in developing mouse somatosensory cortex, endogenous Btbd3 translocate to the cell nucleus in response to neuronal activity and oriente primary dendrites toward active axons in the barrel hollow.

In this presentation, the speaker describes some of their recent efforts to characterize the transcriptome of the developing human brain, and and introduction to the BrainSpan project.

How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.

This lecture covers visualizing extracellular neurotransmitter dynamics

This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted. 

This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page. 

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

This lecture consists of the second half of the introduction to signal transduction, here focusing on cell receptors and signalling cascades.

In this lesson, you will learn about GABAergic interneurons and local inhibition on the circuit level.

This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis, and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.

While the previous lesson in the Neuro4ML course dealt with the mechanisms involved in individual synapses, this lesson discusses how synapses and their neurons' firing patterns may change over time. 

In this lesson, you will learn about how machine learners and computational neuroscientists design and build models of neuronal synapses. 

This lesson goes into the mechanisms behind changes in synaptic function created by learning.

This short talk addresses how to use VisuAlign to make nonlinear adjustments to 2D-to-3D registrations generated by QuickNII. 

This talk aims to provide guidance regarding the myriad labelling methods for histological image data. 

This lesson provides a cross-species comparison of neuron types in the rat and mouse brain. 

This lecture concludes the course with an outline of future directions of the field of neuroscientific research data integration. 

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics. 

This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes.