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Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity.

Difficulty level: Beginner
Duration: 31:22
Speaker: : Paul Triebkorn
Course:

The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

Difficulty level: Beginner
Duration: 55:36
Speaker: : Elissa Chesler
Difficulty level: Beginner
Duration: 43:38
Speaker: : Kent Lloyd

A basic introduction to clinical presentation of schizophrenia, its etiology, and current treatment options.

Difficulty level: Beginner
Duration: 51:49

This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases

Difficulty level: Beginner
Duration: 1:02:29
Speaker: : Nir Giladi

This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.

Difficulty level: Beginner
Duration: 37:36
Speaker: : Anat Achiron

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Difficulty level: Beginner
Duration: 28:29
Speaker: : Carl Petersen

Introduction to the course Cellular Mechanisms of Brain Function.

Difficulty level: Beginner
Duration: 12:20
Speaker: : Carl Petersen

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Difficulty level: Beginner
Duration: 28:29
Speaker: : Carl Petersen

Introduction to the course Cellular Mechanisms of Brain Function.

Difficulty level: Beginner
Duration: 12:20
Speaker: : Carl Petersen

Ion channels and the movement of ions across the cell membrane.

Difficulty level: Beginner
Duration: 28:08
Speaker: : Carl Petersen

Spatiotemporal dynamics of the membrane potential.

Difficulty level: Beginner
Duration: 19:14
Speaker: : Carl Petersen

Action potentials, and biophysics of voltage-gated ion channels.

Difficulty level: Beginner
Duration: 27:47
Speaker: : Carl Petersen

Voltage-gating kinetics of sodium and potassium channels.

Difficulty level: Beginner
Duration: 19:20
Speaker: : Carl Petersen

The ionic basis of the action potential, including the Hodgkin Huxley model.

Difficulty level: Beginner
Duration: 28:29
Speaker: : Carl Petersen

Action potential initiation and propagation.

Difficulty level: Beginner
Duration: 23:16
Speaker: : Carl Petersen

Neurotransmitter release in the presynaptic specialization.

Difficulty level: Beginner
Duration: 21:36
Speaker: : Carl Petersen

Synaptic modulation through diffusing neurotransmitters.

Difficulty level: Beginner
Duration: 23:00
Speaker: : Carl Petersen

Glutamatergic transmission.

Difficulty level: Beginner
Duration: 28:53
Speaker: : Carl Petersen

Glutamate release after an action potential. Resulting post-synaptic potentials in a biophysically realistic situation.

Difficulty level: Beginner
Duration: 29:35
Speaker: : Carl Petersen