This lecture covers structured data, databases, federating neuroscience-relevant databases, ontologies. 

This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases

This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Introduction to the course Cellular Mechanisms of Brain Function.

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Introduction to the course Cellular Mechanisms of Brain Function.

Ion channels and the movement of ions across the cell membrane.

Spatiotemporal dynamics of the membrane potential.

Action potentials, and biophysics of voltage-gated ion channels.

Voltage-gating kinetics of sodium and potassium channels.

The ionic basis of the action potential, including the Hodgkin Huxley model.

Action potential initiation and propagation.

Neurotransmitter release in the presynaptic specialization.

Synaptic modulation through diffusing neurotransmitters.

Glutamatergic transmission.

Glutamate release after an action potential. Resulting post-synaptic potentials in a biophysically realistic situation.

Glutamatergic excitatory neuronal circuits.

Dendritic spines and their function.

GABAergic inhibition and its receptors.