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This tutorial demonstrates how to perform cell-type deconvolution in order to estimate how proportions of cell-types in the brain change in response to various conditions. While these techniques may be useful in addressing a wide range of scientific questions, this tutorial will focus on the cellular changes associated with major depression (MDD). 

Difficulty level: Intermediate
Duration: 1:15:14
Speaker: : Keon Arbabi

This lesson introduces the practical usage of The Virtual Brain (TVB) in its graphical user interface and via python scripts. In the graphical user interface, you are guided through its data repository, simulator, phase plane exploration tool, connectivity editor, stimulus generator, and the provided analyses. The implemented iPython notebooks of TVB are presented, and since they are public, can be used for further exploration of TVB. 

Difficulty level: Beginner
Duration: 1:12:24
Speaker: : Paul Triebkorn

This hands-on tutorial focuses on a brief introduction to the GUI of TVB. You will visualize a structural connectome and use it for simulation. The local neural mass model will be explored through the phase plane viewer and a parameter space exploration will be performed to observe different dynamics of the large-scale brain model.

Difficulty level: Beginner
Duration: 23:21
Speaker: : Paul Triebkorn

Simulate your own stimulation with the TVB graphical user interface. This hands-on shows you how to configure a stimulus for a specific brain region and apply it to the simulation. Afterwards the results are visualized with the TVB 3D viewer.

Difficulty level: Beginner
Duration: 20:59
Speaker: : Paul Triebkorn

Explore how to setup an epileptic seizure simulation with the TVB graphical user interface. This lesson will show you how to program the epileptor model in the brain network to simulate a epileptic seizure originating in the hippocampus. It will also show how to upload and view mouse connectivity data, as well as give a short introduction to the python script interface of TVB.

Difficulty level: Intermediate
Duration: 58:06
Speaker: : Paul Triebkorn

Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface (GUI). Afterwards, the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity.

Difficulty level: Beginner
Duration: 31:22
Speaker: : Paul Triebkorn

Brain network reconstruction from empirical data is of key importance to generate personalized virtual brain models. This lecture will introduce the basic concepts of preprocessing structural, functional and diffusion weighted neuroimages. It highlights the latest methods and pipelines to extract structural as well as functional connectomes according to a multimodal parcellation.

Difficulty level: Intermediate
Duration: 1:17:32
Speaker: : Michael Schirner

Learn how to simulate strokes with the simulation platform, The Virtual Brain. We will go through two papers: Functional Mechanisms of Recovery after Stroke: Modeling with The Virtual Brain and The Virtual Brain: Modeling Biological Correlates of Recovery After Chronic Stroke, and apply the same processes with our own structural connectivity dataset in The Virtual Brain.

Difficulty level: Beginner
Duration: 7:43
Speaker: : Paul Triebkorn

In this lesson you will learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper On the Nature of Seizure Dynamics, which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

Difficulty level: Beginner
Duration: 4:44
Speaker: : Paul Triebkorn

In this lecture we will focus on a paper called The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. We will have a closer look at the equations of the epileptor model and particular the epileptogenicity index, which controls the excitability of each brain region. Subsequently, we will begin to setup the epileptogenic zone in our own brain network model with TVB.

Difficulty level: Beginner
Duration: 6:25
Speaker: : Paul Triebkorn

After introducing the local epileptor model in the previous two videos, we will now use it in a large-scale brain simulation. We again focus on the paper The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. Two simulations with different epileptogenicity across the network are visualized to show the difference in seizure spread across the cortex.

Difficulty level: Beginner
Duration: 6:36
Speaker: : Paul Triebkorn

This lecture gives an overview on the article Individual brain structure and modelling predict seizure propagation, in which 15 subjects with epilepsy were modelled to predict individual epileptogenic zones. With the TVB GUI we will model seizure spread and the effect of lesioning the connectome. The impact of cutting edges in the network on seizure spreading will be visualized.

Difficulty level: Beginner
Duration: 9:39
Speaker: : Paul Triebkorn

This lecture briefly introduces The Virtual Brain (TVB), a multi-scale, multi-modal neuroinformatics platform for full brain network simulations using biologically realistic connectivity, as well as its potential neuroscience applications (e.g., epilepsy cases).

Difficulty level: Beginner
Duration: 8:53
Speaker: : Petra Ritter

This lecture presents two recent clinical case studies using TVB: stroke recovery and dementia (due to Alzheimer’s Disease (AD)). Using a multi-scale neurophysiological model based on empirical multi-modal neuroimaging data, we show how local and global biophysical parameters characterize changes in individualized patient-specific brain dynamics, predict recovery of motor function for stroke patients, and correlate with individual differences in cognition for AD patients.

Difficulty level: Intermediate
Duration: 32:11
Speaker: : Randy McIntosh
Course:

The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

Difficulty level: Beginner
Duration: 55:36
Speaker: : Elissa Chesler

This lesson introduces the EEGLAB toolbox, as well as motivations for its use.

Difficulty level: Beginner
Duration: 15:32
Speaker: : Arnaud Delorme

In this lesson, you will learn about the biological activity which generates and is measured by the EEG signal.

Difficulty level: Beginner
Duration: 6:53
Speaker: : Arnaud Delorme

This lesson goes over the characteristics of EEG signals when analyzed in source space (as opposed to sensor space). 

Difficulty level: Beginner
Duration: 10:56
Speaker: : Arnaud Delorme

This lesson describes the development of EEGLAB as well as to what extent it is used by the research community.

Difficulty level: Beginner
Duration: 6:06
Speaker: : Arnaud Delorme

This lesson provides instruction as to how to build a processing pipeline in EEGLAB for a single participant. 

Difficulty level: Beginner
Duration: 9:20
Speaker: :