Computational models provide a framework for integrating data across spatial scales and for exploring hypotheses about the biological mechanisms underlying neuronal and network dynamics. However, as models increase in complexity, additional barriers emerge to the creation, exchange, and re-use of models. Successful projects have created standards for describing complex models in neuroscience and provide open source tools to address these issues. This lecture provides an overview of these projects and make a case for expanded use of resources in support of reproducibility and validation of models against experimental data.

Introduction to the FAIR Principles and examples of applications of the FAIR Principles in neuroscience. This lecture was part of the 2019 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.

NWB: An ecosystem for neurophysiology data standardization

Learn how to create a standard extracellular electrophysiology dataset in NWB using Python

Learn how to create a standard calcium imaging dataset in NWB using Python

Learn how to create a standard intracellular electrophysiology dataset in NWB

Learn how to use the icephys-metadata extension to enter meta-data detailing your experimental paradigm

Learn how to build and share extensions in NWB

Learn how to build custom APIs for extension

Learn how to handle writing very large data in PyNWB

Learn how to create a standard extracellular electrophysiology dataset in NWB using MATLAB

Learn how to create a standard calcium imaging dataset in NWB using MATLAB

Learn how to create a standard intracellular electrophysiology dataset in NWB

Learn how to handle writing very large data in MatNWB

Overview of the Braintorm package for analyzing extracellular electrophysiology, including preprocessing, spike sorting, trial alignment, and spectrotemporal decomposition

Overview of the CaImAn package, and demonstration of usage with NWB

Overview of the SpikeInterface package, including demonstration of data loading, preprocessing, spike sorting, and comparison of spike sorters

Overview of the NWBWidgets package, including coverage of different data types, and information for building custom widgets within this framework

This lecture covers an Introduction to neuron anatomy and signaling, and different types of models, including the Hodgkin-Huxley model.

Next generation science with Jupyter. This lecture was part of the 2019 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.