This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.
This lesson continues with the second workshop on reproducible science, focusing on additional open source tools for researchers and data scientists, such as the R programming language for data science, as well as associated tools like RStudio and R Markdown. Additionally, users are introduced to Python and iPython notebooks, Google Colab, and are given hands-on tutorials on how to create a Binder environment, as well as various containers in Docker and Singularity.
This lesson gives an in-depth introduction of ethics in the field of artificial intelligence, particularly in the context of its impact on humans and public interest. As the healthcare sector becomes increasingly affected by the implementation of ever stronger AI algorithms, this lecture covers key interests which must be protected going forward, including privacy, consent, human autonomy, inclusiveness, and equity.
This lesson describes a definitional framework for fairness and health equity in the age of the algorithm. While acknowledging the impressive capability of machine learning to positively affect health equity, this talk outlines potential (and actual) pitfalls which come with such powerful tools, ultimately making the case for collaborative, interdisciplinary, and transparent science as a way to operationalize fairness in health equity.
This lesson contains both a lecture and a tutorial component. The lecture (0:00-20:03 of YouTube video) discusses both the need for intersectional approaches in healthcare as well as the impact of neglecting intersectionality in patient populations. The lecture is followed by a practical tutorial in both Python and R on how to assess intersectional bias in datasets. Links to relevant code and data are found below.
This lesson describes the fundamentals of genomics, from central dogma to design and implementation of GWAS, to the computation, analysis, and interpretation of polygenic risk scores.
This lesson contains the slides (pptx) of a lecture discussing the necessary concepts and tools for taking into account population stratification and admixture in the context of genome-wide association studies (GWAS). The free-access software Tractor and its advantages in GWAS are also discussed.
This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes.
This lesson breaks down the principles of Bayesian inference and how it relates to cognitive processes and functions like learning and perception. It is then explained how cognitive models can be built using Bayesian statistics in order to investigate how our brains interface with their environment.
This lesson corresponds to slides 1-64 in the PDF below.
This lecture discusses what defines an integrative approach regarding research and methods, including various study designs and models which are appropriate choices when attempting to bridge data domains; a necessity when whole-person modelling.
Introduction of the Foundations of Machine Learning in Python course - Day 01.
High-Performance Computing and Analytics Lab, University of Bonn
Optimization for machine learning - Day 02 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Linear Algebra for Machine Learning - Day 03 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Support Vector Machines - Day 06 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Decision Trees and Random Forests - Day 07 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Clustering and Density Estimation - Day 08 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Dimensionality Reduction - Day 09 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Introduction to Neural Networks - Day 10 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Introduction to Convolutional Neural Networks - Day 11 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn
Initialization, Optimization, and Regularization - Day 12 lecture of the Foundations of Machine Learning in Python course.
High-Performance Computing and Analytics Lab, University of Bonn