This lecture is part of the Neuromatch Academy (NMA), a massive, interactive online summer school held in 2020 that provided participants with experiences spanning from hands-on modeling experience to meta-science interpretation skills across just about everything that could reasonably be included in the label "computational neuroscience". 

This lecture summarizes the concepts introduced in Model Fitting I and adds two additional concepts: 1) MLE is a frequentist way of looking at the data and the model, with its own limitations. 2) Side-by-side comparisons of bootstrapping and cross-validation.

This lecture is part of the Neuromatch Academy (NMA), a massive, interactive online summer school held in 2020 that provided participants with experiences spanning from hands-on modeling experience to meta-science interpretation skills across just about everything that could reasonably be included in the label "computational neuroscience". 

This lecture provides an overview of generalized linear models (GLM) and contains links to 2 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.

This lecture is part of the Neuromatch Academy (NMA), a massive, interactive online summer school held in 2020 that provided participants with experiences spanning from hands-on modeling experience to meta-science interpretation skills across just about everything that could reasonably be included in the label "computational neuroscience". 

This lecture further develops the concepts introduced in Machine Learning I.

This lecture is part of the Neuromatch Academy (NMA), a massive, interactive online summer school held in 2020 that provided participants with experiences spanning from hands-on modeling experience to meta-science interpretation skills across just about everything that could reasonably be included in the label "computational neuroscience". 

This lecture introduces the core concepts of dimensionality reduction.

This lecture is part of the Neuromatch Academy (NMA), a massive, interactive online summer school held in 2020 that provided participants with experiences spanning from hands-on modeling experience to meta-science interpretation skills across just about everything that could reasonably be included in the label "computational neuroscience". 

This lecture provides an application of dimensionality reduction applied to multi-dimensional neural recordings using brain-computer interfaces with simultaneous spike recordings.

This tutorial covers Generalized Linear Models (GLMs), which are a fundamental framework for supervised learning. In this tutorial, the objective is to model a retinal ganglion cell spike train by fitting a temporal receptive field: first with a Linear-Gaussian GLM (also known as ordinary least-squares regression model) and then with a Poisson GLM (aka "Linear-Nonlinear-Poisson" model). This tutorial also covers a special case of GLMs, logistic regression, and learn how to ensure good model performance. This tutorial is designed to run with retinal ganglion cell spike train data from Uzzell & Chichilnisky 2004.

This tutorial covers multivariate data can be represented in different orthonormal bases. 

Overview of this tutorial:

• Generate correlated multivariate data
• Define an arbitrary orthonormal basis
• Project the data onto the new basis

This tutorial covers how to perform principal component analysis (PCA) by projecting the data onto the eigenvectors of its covariance matrix.

Overview of this tutorial:

• Calculate the eigenvectors of the sample covariance matrix.
• Perform PCA by projecting data onto the eigenvectors of the covariance matrix.
• Plot and explore the eigenvalues.

To quickly refresh your knowledge of eigenvalues and eigenvectors, you can watch this short video (4 minutes) for a geometrical explanation. For a deeper understanding, this in-depth video (17 minutes) provides an excellent basis and is beautifully illustrated.

This tutorial covers how to apply principal component analysis (PCA) for dimensionality reduction, using a classic dataset that is often used to benchmark machine learning algorithms: MNIST. We'll also learn how to use PCA for reconstruction and denoising.

Overview of this tutorial:

• Perform PCA on MNIST
• Calculate the variance explained
• Reconstruct data with different numbers of PCs
• (Bonus) Examine denoising using PCA

You can learn more about MNIST dataset here.

This tutorial covers how dimensionality reduction can be useful for visualizing and inferring structure in your data. To do this, we will compare principal component analysis (PCA) with t-SNE, a nonlinear dimensionality reduction method.

Overview of the tutorial:

• Visualize MNIST in 2D using PCA
• Visualize MNIST in 2D using t-SNE

Neuromatch Academy aims to introduce traditional and emerging tools of computational neuroscience to trainees. It is appropriate for student population ranging from undergraduates to faculty in academic settings and also includes industry professionals. In addition to teaching the technical details of computational methods, Neuromatch Academy also provide a curriculum centered on modern neuroscience concepts taught by leading professors along with explicit instruction on how and why to apply models. 

This lecture introduces the concept of Bayesian statistics and explains why Bayesian statistics are relevant to studying the brain.

This tutorial provides an introduction to Bayesian statistics and covers developing a Bayesian model for localizing sounds based on audio and visual cues. This model will combine prior information about where sounds generally originate with sensory information about the likelihood that a specific sound came from a particular location. The resulting posterior distribution not only allows us to make optimal decision about the sound's origin, but also lets us quantify how uncertain that decision is. Bayesian techniques are therefore useful normative models: the behavior of human or animal subjects can be compared against these models to determine how efficiently they make use of information.

Overview of this tutorial

1. Implement a Gaussian distribution
2. Use Bayes' Theorem to find the posterior from a Gaussian-distributed prior and likelihood.
3. Change the likelihood mean and variance and observe how posterior changes.
4. Advanced (optional): Observe what happens if the prior is a mixture of two gaussians?

In this tutorial, we will use the concepts introduced in tutorial 1 as building blocks to explore more complicated sensory integration and ventriloquism! 

Overview of tutorial

1. Learn more about the problem setting, which we will also use in Tutorial 3
2. Implement a mixture-of-Gaussian prior
3. Explore how that prior produces more complex posteriors

This tutorial covers computing all the necessary steps to perform model inversion (estimate the model parameters such as 𝑝𝑐𝑜𝑚𝑚𝑜𝑛 that generated data similar to that of a participant). We will describe all the steps of the generative model first, and in the last exercise we will use all these steps to estimate the parameter 𝑝𝑐𝑜𝑚𝑚𝑜𝑛 of a single participant using simulated data.

The generative model will be the same Bayesian model we have been using throughout tutorial 2: a mixture of Gaussian prior (common + independent priors) and a Gaussian likelihood.

This tutorial focuses on Bayesian Decision Theory, which combines the posterior with cost functions that allow us to quantify the potential impact of making a decision or choosing an action based on that posterior. Cost functions are therefore critical for turning probabilities into actions!

Overview of this tutorial:

1. Implement three commonly-used cost functions: mean-squared error, absolute error, and zero-one loss
2. Discover the concept of expected loss
3. Choose optimal locations on the posterior that minimize these cost functions

Neuromatch Academy aims to introduce traditional and emerging tools of computational neuroscience to trainees. It is appropriate for student population ranging from undergraduates to faculty in academic settings and also includes industry professionals. In addition to teaching the technical details of computational methods, Neuromatch Academy also provide a curriculum centered on modern neuroscience concepts taught by leading professors along with explicit instruction on how and why to apply models. 

This lecture focuses on advanced uses of Bayesian statistics for understanding the brain.

Neuromatch Academy aims to introduce traditional and emerging tools of computational neuroscience to trainees. It is appropriate for student population ranging from undergraduates to faculty in academic settings and also includes industry professionals. In addition to teaching the technical details of computational methods, Neuromatch Academy also provide a curriculum centered on modern neuroscience concepts taught by leading professors along with explicit instruction on how and why to apply models. 

This lecture provides an introduction to linear systems.

This tutorial covers the behavior of dynamical systems, systems that evolve in time, where the rules by which they evolve in time are described precisely by a differential equation. 

Differential equations are equations that express the rate of change of the state variable 𝑥. One typically describes this rate of change using the derivative of 𝑥 with respect to time (𝑑𝑥/𝑑𝑡) on the left hand side of the differential equation: 𝑑𝑥𝑑𝑡=𝑓(𝑥). A common notational short-hand is to write 𝑥˙ for 𝑑𝑥𝑑𝑡. The dot means "the derivative with respect to time".

Overview of this tutorial:

• Explore and understand the behavior of such systems where 𝑥 is a single variable
• Consider cases where 𝐱 is a state vector representing two variables

This tutorial provides an introduction to the Markov process in a simple example where the state transitions are probabilistic.

Overview of this tutorial:

• Understand Markov processes and history dependence
• Explore the behavior of a two-state telegraph process and understand how its equilibrium distribution is dependent on its parameters

This tutorial builds on how deterministic and stochastic processes can both be a part of a dynamical system by:

• Simulating random walks
• Investigating the mean and variance of a Ornstein-Uhlenbeck (OU) process
• Quantifying the OU process's behavior at equilibrium