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Félix-Antoine Fortin from Calcul Québec gives an introduction to high-performance computing with the Compute Canada network, first providing an overview of use cases for HPC and then a hand-on tutorial.  Though some examples might seem specific to the Calcul Québec, all computing clusters in the Compute Canada network share the same software modules and environments.

 

The lesson was given in the context of the BrainHack School 2020.

Difficulty level: Beginner
Duration: 02:49:34
Speaker: :

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

Difficulty level: Intermediate
Duration: 1:47:22

This tutorial introduces pipelines and methods to compute brain connectomes from fMRI data. With corresponding code and repositories, participants can follow along and learn how to programmatically preprocess, curate, and analyze functional and structural brain data to produce connectivity matrices. 

Difficulty level: Intermediate
Duration: 1:39:04

This lecture and tutorial focuses on measuring human functional brain networks. The lecture and tutorial were part of the 2019 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.

Difficulty level: Intermediate
Duration: 50:44
Speaker: : Caterina Gratton

Lecture on functional brain parcellations and a set of tutorials on bootstrap agregation of stable clusters (BASC) for fMRI brain parcellation which were part of the 2019 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.

Difficulty level: Advanced
Duration: 50:28
Speaker: : Pierre Bellec

Since their introduction in 2016, the FAIR data principles have gained increasing recognition and adoption in global neuroscience.  FAIR defines a set of high-level principles and practices for making digital objects, including data, software, and workflows, Findable, Accessible,  Interoperable, and Reusable.  But FAIR is not a specification;  it leaves many of the specifics up to individual scientific disciplines to define.  INCF has been leading the way in promoting, defining, and implementing FAIR data practices for neuroscience.  We have been bringing together researchers, infrastructure providers, industry, and publishers through our programs and networks.  In this session, we will hear some perspectives on FAIR neuroscience from some of these stakeholders who have been working to develop and use FAIR tools for neuroscience.  We will engage in a discussion on questions such as:  how is neuroscience doing with respect to FAIR?  What have been the successes?  What is currently very difficult? Where does neuroscience need to go?

 

This lecture covers FAIR atlases, from their background, their construction, and how they can be created in line with the FAIR principles.

Difficulty level: Beginner
Duration: 14:24
Speaker: : Heidi Kleven

This lecture covers the history of behaviorism and the ultimate challenge to behaviorism. 

Difficulty level: Beginner
Duration: 1:19:08

This lecture covers various learning theories.

Difficulty level: Beginner
Duration: 1:00:42

This lesson describes the fundamentals of genomics, from central dogma to design and implementation of GWAS, to the computation, analysis, and interpretation of polygenic risk scores. 

Difficulty level: Intermediate
Duration: 1:28:16
Speaker: : Dan Felsky

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics. 

Difficulty level: Intermediate
Duration: 1:27:18
Speaker: : Dan Felsky

This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses. 

Difficulty level: Intermediate
Duration: 1:53:34
Speaker: : Dan Felsky

This lesson contains the slides (pptx) of a lecture discussing the necessary concepts and tools for taking into account population stratification and admixture in the context of genome-wide association studies (GWAS). The free-access software Tractor and its advantages in GWAS are also discussed. 

Difficulty level: Intermediate
Duration:
Speaker: : Dan Felsky

This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes. 

Difficulty level: Intermediate
Duration: 1:29:08

This is a tutorial introducing participants to the basics of RNA-sequencing data and how to analyze its features using Seurat. 

Difficulty level: Intermediate
Duration: 1:19:17
Speaker: : Sonny Chen

This tutorial demonstrates how to perform cell-type deconvolution in order to estimate how proportions of cell-types in the brain change in response to various conditions. While these techniques may be useful in addressing a wide range of scientific questions, this tutorial will focus on the cellular changes associated with major depression (MDD). 

Difficulty level: Intermediate
Duration: 1:15:14
Speaker: : Keon Arbabi

Similarity Network Fusion (SNF) is a computational method for data integration across various kinds of measurements, aimed at taking advantage of the common as well as complementary information in different data types. This workshop walks participants through running SNF on EEG and genomic data using RStudio.

Difficulty level: Intermediate
Duration: 1:21:38
Speaker: : Dan Felsky

How genetics can contribute to our understanding of psychiatric phenotypes.

Difficulty level: Beginner
Duration: 55:15
Speaker: : Sven Cichon

This lesson contains both a lecture and a tutorial component. The lecture (0:00-20:03 of YouTube video) discusses both the need for intersectional approaches in healthcare as well as the impact of neglecting intersectionality in patient populations. The lecture is followed by a practical tutorial in both Python and R on how to assess intersectional bias in datasets. Links to relevant code and data are found below. 

Difficulty level: Beginner
Duration: 52:26

This is a tutorial on designing a Bayesian inference model to map belief trajectories, with emphasis on gaining familiarity with Hierarchical Gaussian Filters (HGFs).

 

This lesson corresponds to slides 65-90 of the PDF below. 

Difficulty level: Intermediate
Duration: 1:15:04
Speaker: : Daniel Hauke

This lecture discusses what defines an integrative approach regarding research and methods, including various study designs and models which are appropriate choices when attempting to bridge data domains; a necessity when whole-person modelling. 

Difficulty level: Beginner
Duration: 1:28:14
Speaker: : Dan Felsky