Tutorial on how to perform multi-scale simulation of Alzheimer's disease on The Virtual Brain Simulation Platform. Authors: L. Stefanovski, P. Triebkorn, M.A. Diaz-Cortes, A. Solodkin, V. Jirsa, A.R. McIntosh, P. Ritter
This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
Audio slides presentation to accompany the paper titled: An automated pipeline for constructing personalized virtual brains from multimodal neuroimaging data. Authors: M. Schirner, S. Rothmeier, V. Jirsa, A.R. McIntosh, P. Ritter.