In this final lecture of the INCF Short Course: Introduction to Neuroinformatics, you will hear about new advances in the application of machine learning methods to clinical neuroscience data. In particular, this talk discusses the performance of SynthSeg, an image segmentation tool for automated analysis of highly heterogeneous brain MRI clinical scans.

Longitudinal Online Research and Imaging System (LORIS) is a web-based data and project management software for neuroimaging research studies. It is an open source framework for storing and processing behavioural, clinical, neuroimaging and genetic data. LORIS also makes it easy to manage large datasets acquired over time in a longitudinal study, or at different locations in a large multi-site study.

This lecture covers the rationale for developing the DAQCORD, a framework for the design, documentation, and reporting of data curation methods in order to advance the scientific rigour, reproducibility, and analysis of data.

This lecture focuses on ontologies for clinical neurosciences.

This talks discusses data sharing in the context of dementia. It explains why data sharing in dementia is important, how data is usually shared in the field and illustrates two examples: the Netherlands Consortium Dementia cohorts and the European Platform for Neurodegenerative Diseases.

This talk introduces data sharing initiatives in Epilepsy, particularly across Europe.

Not long ago, scientists in physiotherapy would claim for the need of big data and large initiatives in the US have already allowed to collect large retrospective data on recovery after brain injury and are working to collect prospective data. In Europe, there is a large field of collaboration in the field of aphasia supported by the European cooperation in Science and Technology that is collecting data on language recovery throughout the world. This lecture discusses recent advances in sharing big data for neurorehabilitation.

This lecture explains the need for data federation in medicine and how it can be achieved.

The Medical Informatics Platform (MIP) is a platform providing federated analytics for diagnosis and research in clinical neuroscience research. The federated analytics is possible thanks to a distributed engine that executes computations and transfers information between the members of the federation (hospital nodes). In this talk the speaker will describe the process of designing and implementing new analytical tools, i.e. statistical and machine learning algorithms.  Mr. Sakellariou will further describe the environment in which these federated algorithms run, the challenges and the available tools, the principles that guide its design and the followed general methodology for each new algorithm. One of the most important challenges which are faced is to design these tools in a way that does not compromise the privacy of the clinical data involved. The speaker will show how to address the main questions when designing such algorithms: how to decompose and distribute the computations and what kind of information to exchange between nodes, in order to comply with the privacy constraint mentioned above. Finally, also the subject of validating these federated algorithms will be briefly touched.

The Medical Informatics Platform (MIP) Dementia had been installed in several memory clinics across Europe allowing them to federate their real-world databases. Research open access databases had also been integrated such as ADNI (Alzheimer’s Dementia Neuroimaging Initiative), reaching a cumulative case load of more than 5,000 patients (major cognitive disorder due to Alzheimer’s disease, other major cognitive disorder, minor cognitive disorder, controls). The statistic and machine learning tools implemented in the MIP allowed researchers to conduct easily federated analyses among Italian memory clinics (Redolfi et al. 2020) and also across borders between the French (Lille), the Swiss (Lausanne) and the Italian (Brescia) datasets.

This talks presents ethics requirements of the Medical Informatics Platform, a data sharing platform for medical data using data federation mechanisms. The talk presents how the Medical Informatics Platform (MIP) works and which ethical requirements need to be considered when working with federated data.

This lecture discusses risk-based anonymization approaches for medical research.

Following the previous lesson on neuronal structure, this lesson discusses neuronal function, particularly focusing on spike triggering and propogation. 

This lesson introduces the practical exercises which accompany the previous lessons on animal and human connectomes in the brain and nervous system. 

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

In this lecture, attendees will learn how Mutant Mouse Resource and Research Center (MMRRC) archives, cryopreserves, and distributes scientifically valuable genetically engineered mouse strains and mouse ES cell lines for the genetics and biomedical research community.

This lesson provides an overview of Neurodata Without Borders (NWB), an ecosystem for neurophysiology data standardization. The lecture also introduces some NWB-enabled tools. 

Learn how to create a standard extracellular electrophysiology dataset in NWB using Python.

Learn how to create a standard calcium imaging dataset in NWB using Python.

In this tutorial, you will learn how to create a standard intracellular electrophysiology dataset in NWB using Python.