This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis, and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
While the previous lesson in the Neuro4ML course dealt with the mechanisms involved in individual synapses, this lesson discusses how synapses and their neurons' firing patterns may change over time.
In this lesson, you will learn about how machine learners and computational neuroscientists design and build models of neuronal synapses.
How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.
This lesson goes into the mechanisms behind changes in synaptic function created by learning.
This is the first of two workshops on reproducibility in science, during which participants are introduced to concepts of FAIR and open science. After discussing the definition of and need for FAIR science, participants are walked through tutorials on installing and using Github and Docker, the powerful, open-source tools for versioning and publishing code and software, respectively.
This lesson contains both a lecture and a tutorial component. The lecture (0:00-20:03 of YouTube video) discusses both the need for intersectional approaches in healthcare as well as the impact of neglecting intersectionality in patient populations. The lecture is followed by a practical tutorial in both Python and R on how to assess intersectional bias in datasets. Links to relevant code and data are found below.
This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics.
This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.
Maximize Your Research With Cloud Workspaces is a talk aimed at researchers who are looking for innovative ways to set up and execute their life science data analyses in a collaborative, extensible, open-source cloud environment. This panel discussion is brought to you by MetaCell and scientists from leading universities who share their experiences of advanced analysis and collaborative learning through the Cloud.
This talk enumerates the challenges regarding data accessibility and reusability inherent in the current scientific publication system, and discusses novel approaches to these challenges, such as the EBRAINS Live Papers platform.
In this lesson, you will learn about how team science unfolds in practice, as well as what are the standards and best practices used by teams, and how well these best practices function and support scientific output.
In this lesson, you will learn about approaches to make the field of neuroscience more open and fair, particularly regarding the integration of equality, diversity, and inclusion (EDI) as guiding principles for team collaboration.
This lesson discusses the topic of credit and contribution in open and FAIR neuroscience, looking through the respective lenses of systems, teams, and people.
In this talk, you will hear about the challenges and costs of being FAIR in the many scientific fields, as well as opportunities to transform the ecology of the academic crediting system.
This lesson consists of a brief discussion around this sessions previous talks.
In this lightning talk, you will learn about BrainGlobe, an initiative which exists to facilitate the development of interoperable Python-based tools for computational neuroanatomy.
This lesson consists of a panel discussion, wrapping up the INCF Neuroinformatics Assembly 2023 workshop Research Workflows for Collaborative Neuroscience.
This talk gives an overview of the complicated nature of sharing of neuroscientific data in an environment of numerous and often conflicting legal systems around the world.
This talk provides an overview of the FAIR-aligned efforts of MATLAB and MathWorks, from the technological building blocks to the open science coordination involved in facilitating greater transparency and efficiency in neuroscience and neuroinformatics.