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In this session the Medical Informatics Platform (MIP) federated analytics is presented. The current and future analytical tools implemented in the MIP will be detailed along with the constructs, tools, processes, and restrictions that formulate the solution provided. MIP is a platform providing advanced federated analytics for diagnosis and research in clinical neuroscience research. It is targeting clinicians, clinical scientists and clinical data scientists. It is designed to help adopt advanced analytics, explore harmonized medical data of neuroimaging, neurophysiological and medical records as well as research cohort datasets, without transferring original clinical data. It can be perceived as a virtual database that seamlessly presents aggregated data from distributed sources, provides access and analyze imaging and clinical data, securely stored in hospitals, research archives and public databases. It leverages and re-uses decentralized patient data and research cohort datasets, without transferring original data. Integrated statistical analysis tools and machine learning algorithms are exposed over harmonized, federated medical data.

Difficulty level: Intermediate
Duration: 15:05

The Medical Informatics Platform (MIP) is a platform providing federated analytics for diagnosis and research in clinical neuroscience research. The federated analytics is possible thanks to a distributed engine that executes computations and transfers information between the members of the federation (hospital nodes). In this talk the speaker will describe the process of designing and implementing new analytical tools, i.e. statistical and machine learning algorithms.  Mr. Sakellariou will further describe the environment in which these federated algorithms run, the challenges and the available tools, the principles that guide its design and the followed general methodology for each new algorithm. One of the most important challenges which are faced is to design these tools in a way that does not compromise the privacy of the clinical data involved. The speaker will show how to address the main questions when designing such algorithms: how to decompose and distribute the computations and what kind of information to exchange between nodes, in order to comply with the privacy constraint mentioned above. Finally, also the subject of validating these federated algorithms will be briefly touched.

Difficulty level: Intermediate
Duration: 20:26
Speaker: : Jason Skellariou

The Medical Informatics Platform (MIP) Dementia had been installed in several memory clinics across Europe allowing them to federate their real-world databases. Research open access databases had also been integrated such as ADNI (Alzheimer’s Dementia Neuroimaging Initiative), reaching a cumulative case load of more than 5,000 patients (major cognitive disorder due to Alzheimer’s disease, other major cognitive disorder, minor cognitive disorder, controls). The statistic and machine learning tools implemented in the MIP allowed researchers to conduct easily federated analyses among Italian memory clinics (Redolfi et al. 2020) and also across borders between the French (Lille), the Swiss (Lausanne) and the Italian (Brescia) datasets.

Difficulty level: Intermediate
Duration: 16:44
Speaker: : Mélanie Leroy

This lecture talks about the usage of knowledge graphs in hospitals and related challenges of semantic interoperability.

Difficulty level: Intermediate
Duration: 24:32

This lecture discusses risk-based anonymization approaches for medical research.

Difficulty level: Intermediate
Duration: 15:43
Speaker: : Fabian Prasser

This lecture covers visualizing extracellular neurotransmitter dynamics

Difficulty level: Beginner
Duration: 23:20

This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted. 

Difficulty level: Intermediate
Duration: 7:03
Speaker: : Marcus Ghosh

This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page. 

Difficulty level: Intermediate
Duration: 12:50
Speaker: : Dan Goodman

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

Difficulty level: Intermediate
Duration: 9:34
Speaker: : Dan Goodman

This lecture consists of the second half of the introduction to signal transduction, here focusing on cell receptors and signalling cascades.

Difficulty level: Beginner
Duration: 41:38

In this lesson, you will learn about GABAergic interneurons and local inhibition on the circuit level.

Difficulty level: Beginner
Duration: 16:27
Speaker: : Carl Petersen

This lecture covers the history of behaviorism and the ultimate challenge to behaviorism. 

Difficulty level: Beginner
Duration: 1:19:08

This lecture covers various learning theories.

Difficulty level: Beginner
Duration: 1:00:42

This lesson characterizes different types of learning in a neuroscientific and cellular context, and various models employed by researchers to investigate the mechanisms involved. 

Difficulty level: Intermediate
Duration: 3:54
Speaker: : Dan Goodman

In this lesson, you will learn about different approaches to modeling learning in neural networks, particularly focusing on system parameters such as firing rates and synaptic weights impact a network. 

Difficulty level: Intermediate
Duration: 9:40
Speaker: : Dan Goodman

How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.

Difficulty level: Beginner
Duration: 1:08:45
Speaker: : Clay Reid

This tutorial introduces pipelines and methods to compute brain connectomes from fMRI data. With corresponding code and repositories, participants can follow along and learn how to programmatically preprocess, curate, and analyze functional and structural brain data to produce connectivity matrices. 

Difficulty level: Intermediate
Duration: 1:39:04

In this lightning talk, you will learn about BrainGlobe, an initiative which exists to facilitate the development of interoperable Python-based tools for computational neuroanatomy.

Difficulty level: Beginner
Duration: 3:33

In this short talk you will learn about The Neural System Laboratory, which aims to develop and implement new technologies for analysis of brain architecture, connectivity, and brain-wide gene and molecular level organization.

Difficulty level: Beginner
Duration: 8:38
Speaker: : Trygve Leergard

In this lecture, you will learn about current methods, approaches, and challenges to studying human neuroanatomy, particularly through the lense of neuroimaging data such as fMRI and diffusion tensor imaging (DTI). 

Difficulty level: Intermediate
Duration: 1:35:14
Speaker: : Matt Glasser