This lecture covers computational principles that growth cones employ to detect and respond to environmental chemotactic gradients, focusing particularly on growth-cone shape dynamics.

In this lecture you will learn that in developing mouse somatosensory cortex, endogenous Btbd3 translocate to the cell nucleus in response to neuronal activity and oriente primary dendrites toward active axons in the barrel hollow.

In this presentation, the speaker describes some of their recent efforts to characterize the transcriptome of the developing human brain, and and introduction to the BrainSpan project.

How does the brain learn? This lecture discusses the roles of development and adult plasticity in shaping functional connectivity.

This lecture covers visualizing extracellular neurotransmitter dynamics

This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted. 

This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page. 

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

This lecture consists of the second half of the introduction to signal transduction, here focusing on cell receptors and signalling cascades.

In this lesson, you will learn about GABAergic interneurons and local inhibition on the circuit level.

This lesson discusses both state-of-the-art detection and prevention schema in working with neurodegenerative diseases. 

This lecture provides an overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the central nervous system. 

This lecture covers the ethical implications of the use of pharmaceuticals to enhance brain functions and was part of the Neuro Day Workshop held by the NeuroSchool of Aix Marseille University.

While the previous lesson in the Neuro4ML course dealt with the mechanisms involved in individual synapses, this lesson discusses how synapses and their neurons' firing patterns may change over time. 

In this lesson, you will learn about how machine learners and computational neuroscientists design and build models of neuronal synapses. 

This lesson goes into the mechanisms behind changes in synaptic function created by learning.

This is the first of two workshops on reproducibility in science, during which participants are introduced to concepts of FAIR and open science. After discussing the definition of and need for FAIR science, participants are walked through tutorials on installing and using Github and Docker, the powerful, open-source tools for versioning and publishing code and software, respectively.

This lesson contains both a lecture and a tutorial component. The lecture (0:00-20:03 of YouTube video) discusses both the need for intersectional approaches in healthcare as well as the impact of neglecting intersectionality in patient populations. The lecture is followed by a practical tutorial in both Python and R on how to assess intersectional bias in datasets. Links to relevant code and data are found below. 

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics. 

This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.