The simulation of the virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved results in clinics. The fundamentals of epilepsy are explained. On this basis, the concept of epilepsy simulation is developed. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

Explore how to setup an epileptic seizure simulation with the TVB graphical user interface. This lesson will show you how to program the epileptor model in the brain network to simulate a epileptic seizure originating in the hippocampus. It will also show how to upload and view mouse connectivity data, as well as give a short introduction to the python script interface of TVB.

Learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper: On the Nature of Seizure Dynamics which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

2nd part of the lecture. This lecture will discuss how understanding and applying simple neuroanatomical rules, one can localize the damage along the neuroaxis, the first crucial step toward making the correct clinical diagnosis and initiating treatment.

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Introduction to the course Cellular Mechanisms of Brain Function.

The ionic basis of the action potential, including the Hodgkin Huxley model. 

Introduction to the course Cellular Mechanisms of Brain Function.

The composition of the cell membrane.

Spatiotemporal dynamics of the membrane potential.

Action potential initiation and propagation.

Synaptic transmission and neurotransmitters

Neurotransmitter release in the presynaptic specialization.

Presynaptic short-term dynamics and plasticity.

Synaptic modulation through diffusing neurotransmitters.

Investigating the structure of synapses with electron microscopy.

Glutamatergic transmission.

Glutamate release after an action potential. Resulting post-synaptic potentials in a biophysically realistic situation.

Glutamatergic excitatory neuronal circuits.

The mechanisms behind changes in synaptic function created by learning.