This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.
This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics.
This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.
This is an introductory lecture on whole-brain modelling, delving into the various spatial scales of neuroscience, neural population models, and whole-brain modelling. Additionally, the clinical applications of building and testing such models are characterized.
This lesson breaks down the principles of Bayesian inference and how it relates to cognitive processes and functions like learning and perception. It is then explained how cognitive models can be built using Bayesian statistics in order to investigate how our brains interface with their environment.
This lesson corresponds to slides 1-64 in the PDF below.
This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page.
This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication?
This tutorial covers the fundamentals of collaborating with Git and GitHub.
This lecture and tutorial focuses on measuring human functional brain networks, as well as how to account for inherent variability within those networks.
This lesson provides an overview of Jupyter notebooks, Jupyter lab, and Binder, as well as their applications within the field of neuroimaging, particularly when it comes to the writing phase of your research.
This lecture gives an overview of how to prepare and preprocess neuroimaging (EEG/MEG) data for use in TVB.
This lesson provides a brief introduction to the Computational Modeling of Neuronal Plasticity.
In this lesson, you will be introducted to a type of neuronal model known as the leaky integrate-and-fire (LIF) model.
This lesson goes over various potential inputs to neuronal synapses, loci of neural communication.
This lesson describes the how and why behind implementing integration time steps as part of a neuronal model.
In this lesson, you will learn about neural spike trains which can be characterized as having a Poisson distribution.
This lesson covers spike-rate adaptation, the process by which a neuron's firing pattern decays to a low, steady-state frequency during the sustained encoding of a stimulus.
This lesson provides a brief explanation of how to implement a neuron's refractory period in a computational model.
In this lesson, you will learn a computational description of the process which tunes neuronal connectivity strength, spike-timing-dependent plasticity (STDP).
This lesson reviews theoretical and mathematical descriptions of correlated spike trains.