This lesson provides an introduction to biologically detailed computational modelling of neural dynamics, including neuron membrane potential simulation and F-I curves.
In this lesson, users learn about the practical differences between MATLAB scripts and functions, as well as how to embed their neuronal simulation into a callable function.
This lesson teaches users how to generate a frequency-current (F-I) curve, which describes the function that relates the net synaptic current (I) flowing into a neuron to its firing rate (F).
This lecture explains the concept of federated analysis in the context of medical data, associated challenges. The lecture also presents an example of hospital federations via the Medical Informatics Platform.
This lecture presents the Medical Informatics Platform's data federation in epilepsy.
This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.
This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics.
This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.
This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes.
This is a tutorial introducing participants to the basics of RNA-sequencing data and how to analyze its features using Seurat.
This tutorial demonstrates how to perform cell-type deconvolution in order to estimate how proportions of cell-types in the brain change in response to various conditions. While these techniques may be useful in addressing a wide range of scientific questions, this tutorial will focus on the cellular changes associated with major depression (MDD).
This is a tutorial on how to simulate neuronal spiking in brain microcircuit models, as well as how to analyze, plot, and visualize the corresponding data.
In this tutorial on simulating whole-brain activity using Python, participants can follow along using corresponding code and repositories, learning the basics of neural oscillatory dynamics, evoked responses and EEG signals, ultimately leading to the design of a network model of whole-brain anatomical connectivity.
This lesson breaks down the principles of Bayesian inference and how it relates to cognitive processes and functions like learning and perception. It is then explained how cognitive models can be built using Bayesian statistics in order to investigate how our brains interface with their environment.
This lesson corresponds to slides 1-64 in the PDF below.
Along the example of a patient with bi-temporal epilepsy, we show step by step how to develop a Virtual Epileptic Patient (VEP) brain model and integrate patient-specific information such as brain connectivity, epileptogenic zone and MRI lesions. The patient's brain network model is then evaluated via simulation, data fitting and mathematical analysis. This lecture demonstrates how to develop novel personalized strategies towards therapy and intervention using TVB.
This lecture focuses on higher-level simulation scenarios using stimulation protocols. We demonstrate how to build stimulation patterns in TVB, and use them in a simulation to induced activity dissipating into experimentally known resting-state networks in human and mouse brain, a well as to obtain EEG recordings reproducing empirical findings of other researchers.
This tutorial provides instruction on how to simulate brain tumors with TVB (reproducing publication: Marinazzo et al. 2020 Neuroimage). This tutorial comprises a didactic video, jupyter notebooks, and full data set for the construction of virtual brains from patients and health controls.
This lecture introduces you to the basics of the Amazon Web Services public cloud. It covers the fundamentals of cloud computing and goes through both the motivations and processes involved in moving your research computing to the cloud.