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This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

Difficulty level: Intermediate
Duration: 1:09:33
Speaker: : Sean Hill

This is the first of two workshops on reproducibility in science, during which participants are introduced to concepts of FAIR and open science. After discussing the definition of and need for FAIR science, participants are walked through tutorials on installing and using Github and Docker, the powerful, open-source tools for versioning and publishing code and software, respectively.

Difficulty level: Intermediate
Duration: 1:20:58

This lesson explains the fundamental principles of neuronal communication, such as neuronal spiking, membrane potentials, and cellular excitability, and how these electrophysiological features of the brain may be modelled and simulated digitally. 

Difficulty level: Intermediate
Duration: 1:20:42
Speaker: : Etay Hay

This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.

Difficulty level: Intermediate
Duration: 1:11:04
Speaker: : Etay Hay

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

Difficulty level: Intermediate
Duration: 1:47:22

This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted. 

Difficulty level: Intermediate
Duration: 7:03
Speaker: : Marcus Ghosh

This lesson delves into the human nervous system and the immense cellular, connectomic, and functional sophistication therein. 

Difficulty level: Intermediate
Duration: 8:41
Speaker: : Marcus Ghosh

This lesson characterizes different types of learning in a neuroscientific and cellular context, and various models employed by researchers to investigate the mechanisms involved. 

Difficulty level: Intermediate
Duration: 3:54
Speaker: : Dan Goodman

This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page. 

Difficulty level: Intermediate
Duration: 12:50
Speaker: : Dan Goodman

This lesson explores how researchers try to understand neural networks, particularly in the case of observing neural activity. 

Difficulty level: Intermediate
Duration: 8:20
Speaker: : Marcus Ghosh

In this lesson you will learn about the motivation behind manipulating neural activity, and what forms that may take in various experimental designs. 

Difficulty level: Intermediate
Duration: 8:42
Speaker: : Marcus Ghosh

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

Difficulty level: Intermediate
Duration: 9:34
Speaker: : Dan Goodman

This lecture provides an introduction to the Brain Imaging Data Structure (BIDS), a standard for organizing human neuroimaging datasets.

Difficulty level: Intermediate
Duration: 56:49

This tutorial covers the fundamentals of collaborating with Git and GitHub.

Difficulty level: Intermediate
Duration: 2:15:50
Speaker: : Elizabeth DuPre