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This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

Difficulty level: Intermediate
Duration: 1:09:33
Speaker: : Sean Hill

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics. 

Difficulty level: Intermediate
Duration: 1:27:18
Speaker: : Dan Felsky

This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes. 

Difficulty level: Intermediate
Duration: 1:29:08

This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.

Difficulty level: Intermediate
Duration: 1:11:04
Speaker: : Etay Hay

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

Difficulty level: Intermediate
Duration: 1:47:22

In this third and final hands-on tutorial from the Research Workflows for Collaborative Neuroscience workshop, you will learn about workflow orchestration using open source tools like DataJoint and Flyte. 

Difficulty level: Intermediate
Duration: 22:36
Speaker: : Daniel Xenes

This lecture describes how to build research workflows, including a demonstrate using DataJoint Elements to build data pipelines.

Difficulty level: Intermediate
Duration: 47:00
Speaker: : Dimitri Yatsenko

This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted. 

Difficulty level: Intermediate
Duration: 7:03
Speaker: : Marcus Ghosh

This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page. 

Difficulty level: Intermediate
Duration: 12:50
Speaker: : Dan Goodman

This lesson explores how researchers try to understand neural networks, particularly in the case of observing neural activity. 

Difficulty level: Intermediate
Duration: 8:20
Speaker: : Marcus Ghosh

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

Difficulty level: Intermediate
Duration: 9:34
Speaker: : Dan Goodman

This lesson describes how DataLad allows you to track and mange both your data and analysis code, thereby facilitating reliable, reproducible, and shareable research.

Difficulty level: Intermediate
Duration: 59:34

This lecture provides an introduction to the Brain Imaging Data Structure (BIDS), a standard for organizing human neuroimaging datasets.

Difficulty level: Intermediate
Duration: 56:49

In this lesson, you will learn about the Python project Nipype, an open-source, community-developed initiative under the umbrella of NiPy. Nipype provides a uniform interface to existing neuroimaging software and facilitates interaction between these packages within a single workflow.

Difficulty level: Intermediate
Duration: 1:25:05
Speaker: : Satrajit Ghosh

This lecture introduces you to the basics of the Amazon Web Services public cloud. It covers the fundamentals of cloud computing and goes through both the motivations and processes involved in moving your research computing to the cloud.

Difficulty level: Intermediate
Duration: 3:09:12

This lecture provides an introduction to entropy in general, and multi-scale entropy (MSE) in particular, highlighting the potential clinical applications of the latter. 

Difficulty level: Intermediate
Duration: 39:05
Speaker: : Jil Meier

This lecture gives an overview of how to prepare and preprocess neuroimaging (EEG/MEG) data for use in TVB.  

Difficulty level: Intermediate
Duration: 1:40:52
Speaker: : Paul Triebkorn

This lecture provides an general introduction to epilepsy, as well as why and how TVB can prove useful in building and testing epileptic models. 

Difficulty level: Intermediate
Duration: 37:12
Speaker: : Julie Courtiol

This lecture covers the rationale for developing the DAQCORD, a framework for the design, documentation, and reporting of data curation methods in order to advance the scientific rigour, reproducibility, and analysis of data.

Difficulty level: Intermediate
Duration: 17:08
Speaker: : Ari Ercole

In this session the Medical Informatics Platform (MIP) federated analytics is presented. The current and future analytical tools implemented in the MIP will be detailed along with the constructs, tools, processes, and restrictions that formulate the solution provided. MIP is a platform providing advanced federated analytics for diagnosis and research in clinical neuroscience research. It is targeting clinicians, clinical scientists and clinical data scientists. It is designed to help adopt advanced analytics, explore harmonized medical data of neuroimaging, neurophysiological and medical records as well as research cohort datasets, without transferring original clinical data. It can be perceived as a virtual database that seamlessly presents aggregated data from distributed sources, provides access and analyze imaging and clinical data, securely stored in hospitals, research archives and public databases. It leverages and re-uses decentralized patient data and research cohort datasets, without transferring original data. Integrated statistical analysis tools and machine learning algorithms are exposed over harmonized, federated medical data.

Difficulty level: Intermediate
Duration: 15:05