Course:

This tutorial demonstrates how to work with neuronal data using MATLAB, including actional potentials and spike counts, orientation tuing curves in visual cortex, and spatial maps of firing rates.

Difficulty level: Intermediate

Duration: 5:17

Speaker: : Mike X. Cohen

Course:

This lesson instructs users on how to import electrophysiological neural data into MATLAB, as well as how to convert spikes to a data matrix.

Difficulty level: Intermediate

Duration: 11:37

Speaker: : Mike X. Cohen

Course:

In this lesson, users will learn how to appropriately sort and bin neural spikes, allowing for the generation of a common and powerful visualization tool in neuroscience, the histogram.

Difficulty level: Intermediate

Duration: 5:31

Speaker: : Mike X. Cohen

Course:

Followers of this lesson will learn how to compute, visualize and quantify the tuning curves of individual neurons.

Difficulty level: Intermediate

Duration: 13:48

Speaker: : Mike X. Cohen

Course:

This lesson demonstrates how to programmatically generate a spatial map of neuronal spike counts using MATLAB.

Difficulty level: Intermediate

Duration: 12:16

Speaker: : Mike X. Cohen

Course:

In this lesson, users are shown how to create a spatial map of neuronal orientation tuning.

Difficulty level: Intermediate

Duration: 13:11

Speaker: : Mike X. Cohen

Course:

This lesson provides an introduction to biologically detailed computational modelling of neural dynamics, including neuron membrane potential simulation and F-I curves.

Difficulty level: Intermediate

Duration: 8:21

Speaker: : Mike X. Cohen

Course:

In this lesson, users learn how to use MATLAB to build an adaptive exponential integrate and fire (AdEx) neuron model.

Difficulty level: Intermediate

Duration: 22:01

Speaker: : Mike X. Cohen

Course:

In this lesson, users learn about the practical differences between MATLAB scripts and functions, as well as how to embed their neuronal simulation into a callable function.

Difficulty level: Intermediate

Duration: 11:20

Speaker: : Mike X. Cohen

Course:

This lesson teaches users how to generate a frequency-current (F-I) curve, which describes the function that relates the net synaptic current (I) flowing into a neuron to its firing rate (F).

Difficulty level: Intermediate

Duration: 20:39

Speaker: : Mike X. Cohen

Course:

This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

Difficulty level: Intermediate

Duration: 1:09:33

Speaker: : Sean Hill

This lesson describes the fundamentals of genomics, from central dogma to design and implementation of GWAS, to the computation, analysis, and interpretation of polygenic risk scores.

Difficulty level: Intermediate

Duration: 1:28:16

Speaker: : Dan Felsky

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics.

Difficulty level: Intermediate

Duration: 1:27:18

Speaker: : Dan Felsky

This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses.

Difficulty level: Intermediate

Duration: 1:53:34

Speaker: : Dan Felsky

This lesson contains the slides (pptx) of a lecture discussing the necessary concepts and tools for taking into account population stratification and admixture in the context of genome-wide association studies (GWAS). The free-access software Tractor and its advantages in GWAS are also discussed.

Difficulty level: Intermediate

Duration:

Speaker: : Dan Felsky

This lesson is an overview of transcriptomics, from fundamental concepts of the central dogma and RNA sequencing at the single-cell level, to how genetic expression underlies diversity in cell phenotypes.

Difficulty level: Intermediate

Duration: 1:29:08

Speaker: : Shreejoy Tripathy

This is a tutorial introducing participants to the basics of RNA-sequencing data and how to analyze its features using Seurat.

Difficulty level: Intermediate

Duration: 1:19:17

Speaker: : Sonny Chen

This tutorial demonstrates how to perform cell-type deconvolution in order to estimate how proportions of cell-types in the brain change in response to various conditions. While these techniques may be useful in addressing a wide range of scientific questions, this tutorial will focus on the cellular changes associated with major depression (MDD).

Difficulty level: Intermediate

Duration: 1:15:14

Speaker: : Keon Arbabi

This lesson explains the fundamental principles of neuronal communication, such as neuronal spiking, membrane potentials, and cellular excitability, and how these electrophysiological features of the brain may be modelled and simulated digitally.

Difficulty level: Intermediate

Duration: 1:20:42

Speaker: : Etay Hay

This is an in-depth guide on EEG signals and their interaction within brain microcircuits. Participants are also shown techniques and software for simulating, analyzing, and visualizing these signals.

Difficulty level: Intermediate

Duration: 1:30:41

Speaker: : Frank Mazza

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