This lecture presents the Medical Informatics Platform's data federation in epilepsy.

This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

This lesson explains the fundamental principles of neuronal communication, such as neuronal spiking, membrane potentials, and cellular excitability, and how these electrophysiological features of the brain may be modelled and simulated digitally. 

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

Along the example of a patient with bi-temporal epilepsy, we show step by step how to develop a Virtual Epileptic Patient (VEP) brain model and integrate patient-specific information such as brain connectivity, epileptogenic zone and MRI lesions. The patient's brain network model is then evaluated via simulation, data fitting and mathematical analysis. This lecture demonstrates how to develop novel personalized strategies towards therapy and intervention using TVB.

This lecture focuses on higher-level simulation scenarios using stimulation protocols. We demonstrate how to build stimulation patterns in TVB, and use them in a simulation to induced activity dissipating into experimentally known resting-state networks in human and mouse brain, a well as to obtain EEG recordings reproducing empirical findings of other researchers.

This lecture and tutorial focuses on measuring human functional brain networks, as well as how to account for inherent variability within those networks. 

This lesson introduces population models and the phase plane, and is part of the The Virtual Brain (TVB) Node 10 Series, a 4-day workshop dedicated to learning about the full brain simulation platform TVB, as well as brain imaging, brain simulation, personalised brain models, and TVB use cases.

This lesson introduces TVB-multi-scale extensions and other TVB tools which facilitate modeling and analyses of multi-scale data. 

This lecture delves into cortical (i.e., surface-based) brain simulations, as well as subcortical (i.e., deep brain) stimulations, covering the definitions, motivations, and implementations of both. 

This lecture provides an introduction to entropy in general, and multi-scale entropy (MSE) in particular, highlighting the potential clinical applications of the latter. 

This lecture gives an overview of how to prepare and preprocess neuroimaging (EEG/MEG) data for use in TVB.  

In this lecture, you will learn about various neuroinformatic resources which allow for 3D reconstruction of brain models. 

This lecture provides an general introduction to epilepsy, as well as why and how TVB can prove useful in building and testing epileptic models. 

This lesson provides a brief introduction to the Computational Modeling of Neuronal Plasticity.

In this lesson, you will be introducted to a type of neuronal model known as the leaky integrate-and-fire (LIF) model.

This lesson goes over various potential inputs to neuronal synapses, loci of neural communication.

This lesson describes the how and why behind implementing integration time steps as part of a neuronal model.

In this lesson, you will learn about neural spike trains which can be characterized as having a Poisson distribution.

This lesson covers spike-rate adaptation, the process by which a neuron's firing pattern decays to a low, steady-state frequency during the sustained encoding of a stimulus.