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This lesson is a general overview of overarching concepts in neuroinformatics research, with a particular focus on clinical approaches to defining, measuring, studying, diagnosing, and treating various brain disorders. Also described are the complex, multi-level nature of brain disorders and the data associated with them, from genes and individual cells up to cortical microcircuits and whole-brain network dynamics. Given the heterogeneity of brain disorders and their underlying mechanisms, this lesson lays out a case for multiscale neuroscience data integration.

Difficulty level: Intermediate
Duration: 1:09:33
Speaker: : Sean Hill

This is the first of two workshops on reproducibility in science, during which participants are introduced to concepts of FAIR and open science. After discussing the definition of and need for FAIR science, participants are walked through tutorials on installing and using Github and Docker, the powerful, open-source tools for versioning and publishing code and software, respectively.

Difficulty level: Intermediate
Duration: 1:20:58

This is a hands-on tutorial on PLINK, the open source whole genome association analysis toolset. The aims of this tutorial are to teach users how to perform basic quality control on genetic datasets, as well as to identify and understand GWAS summary statistics. 

Difficulty level: Intermediate
Duration: 1:27:18
Speaker: : Dan Felsky

This is a tutorial on using the open-source software PRSice to calculate a set of polygenic risk scores (PRS) for a study sample. Users will also learn how to read PRS into R, visualize distributions, and perform basic association analyses. 

Difficulty level: Intermediate
Duration: 1:53:34
Speaker: : Dan Felsky

This is a continuation of the talk on the cellular mechanisms of neuronal communication, this time at the level of brain microcircuits and associated global signals like those measureable by electroencephalography (EEG). This lecture also discusses EEG biomarkers in mental health disorders, and how those cortical signatures may be simulated digitally.

Difficulty level: Intermediate
Duration: 1:11:04
Speaker: : Etay Hay

This lesson describes the principles underlying functional magnetic resonance imaging (fMRI), diffusion-weighted imaging (DWI), tractography, and parcellation. These tools and concepts are explained in a broader context of neural connectivity and mental health. 

Difficulty level: Intermediate
Duration: 1:47:22

This tutorial introduces pipelines and methods to compute brain connectomes from fMRI data. With corresponding code and repositories, participants can follow along and learn how to programmatically preprocess, curate, and analyze functional and structural brain data to produce connectivity matrices. 

Difficulty level: Intermediate
Duration: 1:39:04

This is an introductory lecture on whole-brain modelling, delving into the various spatial scales of neuroscience, neural population models, and whole-brain modelling. Additionally, the clinical applications of building and testing such models are characterized. 

Difficulty level: Intermediate
Duration: 1:24:44
Speaker: : John Griffiths

This lecture aims to help researchers, students, and health care professionals understand the place for neuroinformatics in the patient journey using the exemplar of an epilepsy patient. 

Difficulty level: Intermediate
Duration: 1:32:53

This lesson briefly goes over the outline of the Neuroscience for Machine Learners course. 

Difficulty level: Intermediate
Duration: 3:05
Speaker: : Dan Goodman

This lesson goes over the basic mechanisms of neural synapses, the space between neurons where signals may be transmitted. 

Difficulty level: Intermediate
Duration: 7:03
Speaker: : Marcus Ghosh

This lesson introduces the practical exercises which accompany the previous lessons on animal and human connectomes in the brain and nervous system. 

Difficulty level: Intermediate
Duration: 4:10
Speaker: : Dan Goodman

This lesson describes spike timing-dependent plasticity (STDP), a biological process that adjusts the strength of connections between neurons in the brain, and how one can implement or mimic this process in a computational model. You will also find links for practical exercises at the bottom of this page. 

Difficulty level: Intermediate
Duration: 12:50
Speaker: : Dan Goodman

This lesson discusses a gripping neuroscientific question: why have neurons developed the discrete action potential, or spike, as a principle method of communication? 

Difficulty level: Intermediate
Duration: 9:34
Speaker: : Dan Goodman

This tutorial covers the fundamentals of collaborating with Git and GitHub.

Difficulty level: Intermediate
Duration: 2:15:50
Speaker: : Elizabeth DuPre

This lecture and tutorial focuses on measuring human functional brain networks, as well as how to account for inherent variability within those networks. 

Difficulty level: Intermediate
Duration: 50:44
Speaker: : Caterina Gratton

This lesson provides an overview of Jupyter notebooks, Jupyter lab, and Binder, as well as their applications within the field of neuroimaging, particularly when it comes to the writing phase of your research. 

Difficulty level: Intermediate
Duration: 50:28
Speaker: : Elizabeth DuPre

This lecture provides an introduction to entropy in general, and multi-scale entropy (MSE) in particular, highlighting the potential clinical applications of the latter. 

Difficulty level: Intermediate
Duration: 39:05
Speaker: : Jil Meier

This lecture provides an general introduction to epilepsy, as well as why and how TVB can prove useful in building and testing epileptic models. 

Difficulty level: Intermediate
Duration: 37:12
Speaker: : Julie Courtiol

This lesson provides a brief introduction to the Computational Modeling of Neuronal Plasticity.

Difficulty level: Intermediate
Duration: 0:40