In this lesson, the simulation of a virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved clinical results. You will learn about the fundamentals of epilepsy, as well as the concepts underlying epilepsy simulation. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

In this lesson you will learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper On the Nature of Seizure Dynamics, which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

This lecture provides an introductory overview of some of the most important concepts in software engineering.

This lesson provides an overview of the database of Genotypes and Phenotypes (dbGaP), which was developed to archive and distribute the data and results from studies that have investigated the interaction of genotype and phenotype in humans.

This talk describes the NIH-funded SPARC Data Structure, and how this project navigates ontology development while keeping in mind the FAIR science principles. 

This lecture covers structured data, databases, federating neuroscience-relevant databases, and ontologies. 

This lecture covers FAIR atlases, including their background and construction, as well as how they can be created in line with the FAIR principles.

This lecture provides an introduction to optogenetics, a biological technique to control the activity of neurons or other cell types with light.

This primer on optogenetics primer discusses how to manipulate neuronal populations with light at millisecond resolution and offers possible applications such as curing the blind and "playing the piano" with cortical neurons.

This lecture covers the description and characterization of an input-output relationship in a information-theoretic context. 

This lesson is part 1 of 2 of a tutorial on statistical models for neural data.

This lesson is part 2 of 2 of a tutorial on statistical models for neural data.

From the retina to the superior colliculus, the lateral geniculate nucleus into primary visual cortex and beyond, this lecture gives a tour of the mammalian visual system highlighting the Nobel-prize winning discoveries of Hubel & Wiesel.

From Universal Turing Machines to McCulloch-Pitts and Hopfield associative memory networks, this lecture explains what is meant by computation.

In this lesson you will learn about ion channels and the movement of ions across the cell membrane, one of the key mechanisms underlying neuronal communication. 

This talk enumerates the challenges regarding data accessibility and reusability inherent in the current scientific publication system, and discusses novel approaches to these challenges, such as the EBRAINS Live Papers platform. 

This lesson aims to define computational neuroscience in general terms, while providing specific examples of highly successful computational neuroscience projects. 

This lesson covers membrane potential of neurons, and how parameters around this potential have direct consequences on cellular communication at both the individual and population level. 

In this lesson you will learn about neurons' ability to generate signals called action potentials, and biophysics of voltage-gated ion channels.