This lecture provides an overview of depression (epidemiology and course of the disorder), clinical presentation, somatic co-morbidity, and treatment options.
An overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the Central Nervous System.
Introduction to the types of glial cells, homeostasis (influence of cerebral blood flow and influence on neurons), insulation and protection of axons (myelin sheath; nodes of Ranvier), microglia and reactions of the CNS to injury.
The landscape of scientific research is changing. Today’s researchers need to participate in large-scale collaborations, obtain and manage funding, share data, publish, and undertake knowledge translation activities in order to be successful. As per these increasing demands, Science Management is now a vital piece of the environment.
Audio slides presentation to accompany the paper titled: An automated pipeline for constructing personalized virtual brains from multimodal neuroimaging data. Authors: M. Schirner, S. Rothmeier, V. Jirsa, A.R. McIntosh, P. Ritter.
This lecture on model types introduces the advantages of modeling, provide examples of different model types, and explain what modeling is all about. This lecture contains links to 3 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.
This lecture focuses on how to get from a scientific question to a model using concrete examples. We will present a 10-step practical guide on how to succeed in modeling. This lecture contains links to 2 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.
This lecture formalizes modeling as a decision process that is constrained by a precise problem statement and specific model goals. We provide real-life examples on how model building is usually less linear than presented in Modeling Practice I.
This lecture focuses on the purpose of model fitting, approaches to model fitting, model fitting for linear models, and how to assess the quality and compare model fits. We will present a 10-step practical guide on how to succeed in modeling.
This lecture summarizes the concepts introduced in Model Fitting I and adds two additional concepts: 1) MLE is a frequentist way of looking at the data and the model, with its own limitations. 2) Side-by-side comparisons of bootstrapping and cross-validation.
This lecture provides an overview of generalized linear models (GLM) and contains links to 2 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.
This lecture further develops the concepts introduced in Machine Learning I.
This lecture introduces the core concepts of dimensionality reduction.
This lecture provides an application of dimensionality reduction applied to multi-dimensional neural recordings using brain-computer interfaces with simultaneous spike recordings.
This tutorial covers Generalized Linear Models (GLMs), which are a fundamental framework for supervised learning. In this tutorial, the objective is to model a retinal ganglion cell spike train by fitting a temporal receptive field: first with a Linear-Gaussian GLM (also known as ordinary least-squares regression model) and then with a Poisson GLM (aka "Linear-Nonlinear-Poisson" model). This tutorial also covers a special case of GLMs, logistic regression, and learn how to ensure good model performance. This tutorial is designed to run with retinal ganglion cell spike train data from Uzzell & Chichilnisky 2004.
This tutorial covers multivariate data can be represented in different orthonormal bases.
Overview of this tutorial: