This lecture focuses on how the immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory, and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss.
This lecture will highlight our current understanding and recent developments in the field of neurodegenerative disease research, as well as the future of diagnostics and treatment of neurodegenerative diseases
Audio slides presentation to accompany the paper titled: An automated pipeline for constructing personalized virtual brains from multimodal neuroimaging data. Authors: M. Schirner, S. Rothmeier, V. Jirsa, A.R. McIntosh, P. Ritter.
This lecture on model types introduces the advantages of modeling, provide examples of different model types, and explain what modeling is all about. This lecture contains links to 3 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.
This lecture focuses on how to get from a scientific question to a model using concrete examples. We will present a 10-step practical guide on how to succeed in modeling. This lecture contains links to 2 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.
This lecture formalizes modeling as a decision process that is constrained by a precise problem statement and specific model goals. We provide real-life examples on how model building is usually less linear than presented in Modeling Practice I.
This lecture focuses on the purpose of model fitting, approaches to model fitting, model fitting for linear models, and how to assess the quality and compare model fits. We will present a 10-step practical guide on how to succeed in modeling.
This lecture summarizes the concepts introduced in Model Fitting I and adds two additional concepts: 1) MLE is a frequentist way of looking at the data and the model, with its own limitations. 2) Side-by-side comparisons of bootstrapping and cross-validation.
This lecture provides an overview of generalized linear models (GLM) and contains links to 2 tutorials, lecture/tutorial slides, suggested reading list, and 3 recorded question and answer sessions.
This lecture further develops the concepts introduced in Machine Learning I.
This lecture introduces the core concepts of dimensionality reduction.
This lecture provides an application of dimensionality reduction applied to multi-dimensional neural recordings using brain-computer interfaces with simultaneous spike recordings.
This tutorial covers Generalized Linear Models (GLMs), which are a fundamental framework for supervised learning. In this tutorial, the objective is to model a retinal ganglion cell spike train by fitting a temporal receptive field: first with a Linear-Gaussian GLM (also known as ordinary least-squares regression model) and then with a Poisson GLM (aka "Linear-Nonlinear-Poisson" model). This tutorial also covers a special case of GLMs, logistic regression, and learn how to ensure good model performance. This tutorial is designed to run with retinal ganglion cell spike train data from Uzzell & Chichilnisky 2004.
This tutorial covers multivariate data can be represented in different orthonormal bases.
Overview of this tutorial:
This tutorial covers how to perform principal component analysis (PCA) by projecting the data onto the eigenvectors of its covariance matrix.
Overview of this tutorial:
To quickly refresh your knowledge of eigenvalues and eigenvectors, you can watch this short video (4 minutes) for a geometrical explanation. For a deeper understanding, this in-depth video (17 minutes) provides an excellent basis and is beautifully illustrated.