Learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper: On the Nature of Seizure Dynamics which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.
In this lecture we will focus on a paper called “The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread”. Within their work, the authors used the epileptor model to simulate a patient's individual seizure. To understand the concept we will have a closer look at the equations of the epileptor model and particular the epileptogenicity index which controls the excitability of each brain region. Subsequently, we will begin to setup the epileptogenic zone in our own brain network model with TVB.
After introducing the local epileptor model in the previous 2 videos we will now use it in a large scale brain simulation. We again focus on the paper “The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread”. Two simulations with different epileptogenicity across the network are visualized to show the difference in seizure spread across the cortex.
This lecture gives an overview on the article “Individual brain structure and modelling predict seizure propagation” where 15 subjects with epilepsy were modelled to predict individual epileptogenic zones. With the TVB GUI we will model seizure spread and the effect of lesioning the connectome. The impact of cutting edges in the network on seizure spreading will be visualized.
This lecture briefly introduces The Virtual Brain (TVB), a multi-scale, multi-modal neuroinformatics platform for full brain network simulations using biologically realistic connectivity, as well as its potential neuroscience applications: for example with epilepsy.
This talk highlights a set of platform technologies, software, and data collections that close and shorten the feedback cycle in research.