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The simulation of the virtual epileptic patient is presented as an example of advanced brain simulation as a translational approach to deliver improved results in clinics. The fundamentals of epilepsy are explained. On this basis, the concept of epilepsy simulation is developed. By using an iPython notebook, the detailed process of this approach is explained step by step. In the end, you are able to perform simple epilepsy simulations your own.

Difficulty level: Beginner
Duration: 1:28:53
Speaker: : Julie Courtiol

Learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper: On the Nature of Seizure Dynamics which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

Difficulty level: Beginner
Duration: 4:44
Speaker: : Paul Triebkorn

Tutorial describing the basic search and navigation features of the Allen Mouse Brain Atlas

Difficulty level: Beginner
Duration: 6:40
Speaker: : Unknown

Tutorial describing the basic search and navigation features of the Allen Developing Mouse Brain Atlas

Difficulty level: Beginner
Duration: 6:35
Speaker: : Unknown

This tutorial demonstrates how to use the differential search feature of the Allen Mouse Brain Atlas to find gene markers for different regions of the brain and to visualize this gene expression in three-dimensional space. Differential search is also available for the Allen Developing Mouse Brain Atlas and the Allen Human Brain Atlas.

Difficulty level: Beginner
Duration: 6:31
Speaker: : Unknown
Course:

The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.

Difficulty level: Beginner
Duration: 55:36
Speaker: : Elissa Chesler

GeneWeaver is a web application for the integrated cross-species analysis of functional genomics data to find convergent evidence from heterogeneous sources. The application consists of a large database of gene sets curated from multiple public data resources and curated submissions, along with a suite of analysis tools designed to allow flexible, customized workflows through web-based interactive analysis or scripted API driven analysis. Gene sets come from multiple widely studied species and include ontology annotations, brain gene expression atlases, systems genetic study results, gene regulatory information, pathway databases, drug interaction databases and many other sources. Users can retrieve, store, analyze and share gene sets through a graded access system. Analysis tools are based on combinatorics and statistical methods for comparing, contrasting and classifying gene sets based on their members.

Difficulty level: Beginner
Duration: 25:53
Speaker: :

Research Resource Identifiers (RRIDs) are ID numbers assigned to help researchers cite key resources (antibodies, model organisms and software projects) in the biomedical literature to improve transparency of research methods.

Difficulty level: Beginner
Duration: 1:01:36
Speaker: : Maryann Martone

Computational models provide a framework for integrating data across spatial scales and for exploring hypotheses about the biological mechanisms underlying neuronal and network dynamics. However, as models increase in complexity, additional barriers emerge to the creation, exchange, and re-use of models. Successful projects have created standards for describing complex models in neuroscience and provide open source tools to address these issues. This lecture provides an overview of these projects and make a case for expanded use of resources in support of reproducibility and validation of models against experimental data.

Difficulty level: Beginner
Duration: 1:00:39
Speaker: : Sharon Crook

Introduction to the FAIR Principles and examples of applications of the FAIR Principles in neuroscience. This lecture was part of the 2019 Neurohackademy, a 2-week hands-on summer institute in neuroimaging and data science held at the University of Washington eScience Institute.

Difficulty level: Beginner
Duration: 55:57

Tutorial describing the basic features of the Brain Explorer® 3-D viewer for the mouse brain

Difficulty level: Beginner
Duration: 6:41
Speaker: : Unknown

This lecture covers an Introduction to neuron anatomy and signaling, and different types of models, including the Hodgkin-Huxley model.

Difficulty level: Beginner
Duration: 1:23:01
Speaker: : Gaute Einevoll

Neuroethics has been described as containing at least two components - the neuroscience of ethics and the ethics of neuroscience. The first involves neuroscientific theories, research, and neuro-imaging focused on how the brain arrives at moral decisions and actions, which challenge existing descriptive theories of how humans develop moral thinking and make ethical decisions. The second, ethics of neuroscience, involves applying normative theories about what is right, good and fair to ethical questions raised by neuroscientific research and new technologies, such as how to balance the public benefit of “big data” neuroscience while protecting individual privacy and norms of informed consent.

Difficulty level: Beginner
Duration: 38:49

The HBP as an ICT flagship project crucially relies on ICT and will contribute important input into the development of new computing principles and artefacts. Individuals working on the HBP should therefore be aware of the long history of ethical issues discussed in computing. The discourse on ethics and computing can be traced back to Norbert Wiener and the very beginning of digital computing. From the 1970s and 80s it has developed into an active discussion involving academics from various disciplines, professional bodies and industry.

Difficulty level: Beginner
Duration: 46:12
Speaker: : Bernd Stahl

Like any transformative technology, intelligent robotics has the potential for huge benefit, but is not without ethical or societal risk. In this lecture, I will explore two questions. Firstly, the increasingly urgent question of the ethical use of robots: are there particular applications of robots that should be proscribed, in eldercare, or surveillance, or war fighting for example? When intelligent autonomous robots make mistakes, as they inevitably will, who should be held to account? Secondly, I will consider the longer-term question of whether intelligent robots themselves could or should be ethical. Seventy years ago Isaac Asimov created his fictional Three Laws of Robotics. Is there now a realistic prospect that we could build a robot that is Three Laws Safe?

Difficulty level: Beginner
Duration: 31:35
Speaker: : Alan Winfield

In the face of perceived public concerns about technological innovations, leading national and international bodies increasingly argue that there must be ‘dialogue' between policy makers, scientific researchers, civil society organizations and members of the public, to shape the pathways of technology development in a way that meets societal needs and gains public trust. This is not new, of course, and such concerns go back at least to the debates over the development of nuclear technologies and campaigns for social responsibility in science. Major funding bodies in the UK, Europe and elsewhere are now addressing this issue by insisting on Responsible Research and Innovation (RRI) in the development of emerging technology. Biotechnologies such as synthetic biology and neurotechnologies have become a particular focus of RRI, partly because of the belief that these are risky technologies involving tinkering with the very building blocks of life, and perhaps even with human nature. With my fellow researchers, I have been involved in trying to develop Responsible Research and Innovation in these technologies for several years.

Difficulty level: Beginner
Duration: 50:15
Speaker: : Nikolas Rose

In this lecture, I consider some of the key social and ethical issues raised by the ‘big brain projects’ currently under way in Europe, the USA, China, Japan and many other regions. I will draw upon our own experience in the ‘ Foresight Lab’ of the HBP to discuss the ways in which these can usefully be approached from the perspective of responsible research and innovation and the AREA approach - anticipation, reflection, engagement and action. These include data protection, privacy and data governance; the search for ‘neural signatures’ of psychaitric and neurological disorders; ‘dual use’ or the military use of developments initially intended for clinical and civilian purposes; brain-computer interfaces and neural prosthetics; and the use of animals in brain research. Following a brief discussion of the challenges of translation from the lab to the real world, I will conclude by arguing that success in contemporary scientific research and innovation is best assured by openness, collaboration, sharing with fellow researchers; robust systems of data governance involving lay persons; frankness about realities of scientific research and innovation with fellow citizens; realism about complexities of links between researchers, publics and private enterprise; and understanding and engaging with the realities of science today in the real world.

Difficulty level: Beginner
Duration: 53:08
Speaker: : Nikolas Rose

The UK Royal Society in its 2012 study of Neuroscience, conflict and security had as its first recommendation that: “There needs to be fresh effort by the appropriate professional bodies to inculcate the awareness of the dual-use challenge (i.e., knowledge and technologies used for beneficial purposes can also be misused for harmful purposes) among neuroscientists at an early stage of their training.” There can be little doubt that the need to raise awareness of this challenge remains among practicing neuroscientists today. This lecture aims to give an introduction and overview of the dual-use challenge as it applies to neuroscience today and will apply in coming decades.

Difficulty level: Beginner
Duration: 40:11
Speaker: : Malcolm Dando

What is Ethics in biomedical research? In this case the ethics we talk about is how we think we can use animals in biomedical research and what we gain from the experimental setup of experiments. We will talk about “a common set of values” and how 3R engagement can make a difference to experimental procedures and a progress in the positive outcome of experimental procedures and results and scientific papers of the future.

Difficulty level: Beginner
Duration: 51:04

Artificial intelligence (AI) is increasingly affecting almost all areas of life from jobs, healthcare and entertainment to public safety and defense. While advances in AI are associated with new opportunities for economic growth and well-being, they at the same time raise major ethical concerns about AI impact on social equality, transparency and accountability. In recent years, these issues have acquired a prominent role on the agendas of policy-makers around the world. Today the need to facilitate beneficial development of AI and regulate it in the public interest is regularly addressed in speeches of political leaders and policy documents prepared by national governments, international organizations, experts, consulting companies and stakeholders.

Difficulty level: Beginner
Duration: 55:13
Speaker: : Rafael Frias