Learn how to simulate strokes with the simulation platform, The Virtual Brain. We will go through two papers: Functional Mechanisms of Recovery after Stroke: Modeling with The Virtual Brain and The Virtual Brain: Modeling Biological Correlates of Recovery After Chronic Stroke, and apply the same processes with our own structural connectivity dataset in The Virtual Brain.

In this lesson you will learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper On the Nature of Seizure Dynamics, which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

In this lecture we will focus on a paper called The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. We will have a closer look at the equations of the epileptor model and particular the epileptogenicity index, which controls the excitability of each brain region. Subsequently, we will begin to setup the epileptogenic zone in our own brain network model with TVB.

After introducing the local epileptor model in the previous two videos, we will now use it in a large-scale brain simulation. We again focus on the paper The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. Two simulations with different epileptogenicity across the network are visualized to show the difference in seizure spread across the cortex.

This lecture gives an overview on the article Individual brain structure and modelling predict seizure propagation, in which 15 subjects with epilepsy were modelled to predict individual epileptogenic zones. With the TVB GUI we will model seizure spread and the effect of lesioning the connectome. The impact of cutting edges in the network on seizure spreading will be visualized.

This lecture briefly introduces The Virtual Brain (TVB), a multi-scale, multi-modal neuroinformatics platform for full brain network simulations using biologically realistic connectivity, as well as its potential neuroscience applications (e.g., epilepsy cases).

This lecture presents two recent clinical case studies using TVB: stroke recovery and dementia (due to Alzheimer’s Disease (AD)). Using a multi-scale neurophysiological model based on empirical multi-modal neuroimaging data, we show how local and global biophysical parameters characterize changes in individualized patient-specific brain dynamics, predict recovery of motor function for stroke patients, and correlate with individual differences in cognition for AD patients.

This talk deals with Identifiers.org, a central infrastructure for findable, accessible, interoperable and re-usable (FAIR) data, which provides a range of services  to promote the citability of individual data providers and integration with e-infrastructures.

This lecture provides an overview of the technology and demonstration of how Hypothes.is is being used within biomedicine. 

This lesson introduces the EEGLAB toolbox, as well as motivations for its use.

In this lesson, you will learn about the biological activity which generates and is measured by the EEG signal.

This lesson goes over the characteristics of EEG signals when analyzed in source space (as opposed to sensor space). 

This lesson describes the development of EEGLAB as well as to what extent it is used by the research community.

This lesson provides instruction as to how to build a processing pipeline in EEGLAB for a single participant. 

Whereas the previous lesson of this course outlined how to build a processing pipeline for a single participant, this lesson discusses analysis pipelines for multiple participants simultaneously. 

In addition to outlining the motivations behind preprocessing EEG data in general, this lesson covers the first step in preprocessing data with EEGLAB, importing raw data. 

Continuing along the EEGLAB preprocessing pipeline, this tutorial walks users through how to import data events as well as EEG channel locations.

This tutorial instructs users how to visually inspect partially pre-processed neuroimaging data in EEGLAB, specifically how to use the data browser to investigate specific channels, epochs, or events for removable artifacts, biological (e.g., eye blinks, muscle movements, heartbeat) or otherwise (e.g., corrupt channel, line noise). 

This tutorial provides instruction on how to use EEGLAB to further preprocess EEG datasets by identifying and discarding bad channels which, if left unaddressed, can corrupt and confound subsequent analysis steps. 

Users following this tutorial will learn how to identify and discard bad EEG data segments using the MATLAB toolbox EEGLAB.