Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity.
In this lecture, the speaker demonstrates Neurokernel's module interfacing feature by using it to integrate independently developed models of olfactory and vision LPUs based upon experimentally obtained connectivity information.
The Mouse Phenome Database (MPD) provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD ensures rigorous curation of phenotype data and supporting documentation using relevant ontologies and controlled vocabularies. As a repository of curated and integrated data, MPD provides a means to access/re-use baseline data, as well as allows users to identify sensitized backgrounds for making new mouse models with genome editing technologies, analyze trait co-inheritance, benchmark assays in their own laboratories, and many other research applications. MPD’s primary source of funding is NIDA. For this reason, a majority of MPD data is neuro- and behavior-related.
This lecture covers modeling the neuron in silicon, modeling vision and audition and sensory fusion using a deep network.
Presentation of past and present neurocomputing approaches and hybrid analog/digital circuits that directly emulate the properties of neurons and synapses.
Presentation of the Brian neural simulator, where models are defined directly by their mathematical equations and code is automatically generated for each specific target.
The lecture covers a brief introduction to neuromorphic engineering, some of the neuromorphic networks that the speaker has developed, and their potential applications, particularly in machine learning.
2nd part of the lecture. Introduction to cell receptors and signalling cascades
An overview of some of the essential concepts in neuropharmacology (e.g. receptor binding, agonism, antagonism), an introduction to pharmacodynamics and pharmacokinetics, and an overview of the drug discovery process relative to diseases of the Central Nervous System.